grant
Pain Outcomes Associated with Exogenous Hormone Therapy in Adults
Organization UNIVERSITY OF KANSAS MEDICAL CENTERLocation KANSAS CITY, UNITED STATESPosted 18 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAmericanAndrogen AntagonistsAndrogen TherapyAndrogenic AgentsAndrogenic CompoundsAndrogensAnti-AndrogenAnti-Androgen AgentsAnti-androgen TherapyAnti-androgen TreatmentAreaBiologicalBrainBrain Nervous SystemBrain regionCNS Nervous SystemCNS processingCell Communication and SignalingCell SignalingCentral Nervous SystemChronicChronic low back painChronic pain syndromeClassificationClinicalCorpus Luteum HormoneDelta4-pregnene-3,20-dioneDevelopmentDiffuse Myofascial Pain SyndromeDisparitiesDisparityDysfunctionEmotionalEmotional well beingEncephalonEndocrine Gland SecretionEndocrine TherapyEstrogensExogenous Hormone TherapyExogenous Hormone UseFatigueFeels wellFemaleFibromyalgiaFibromyositis-Fibromyalgia SyndromeFibrositisFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderGonadal Steroid HormonesHealthHormonalHormonal TherapyHormone ReceptorHormonesIncidenceIndividualInterventionInterviewIntracellular Communication and SignalingKnowledgeLack of EnergyMPD syndromeMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMoodsMuscular RheumatismNMR ImagingNMR TomographyNeuraxisNeurobiologyNociceptionNormal mental conditionNormal mental stateNormal psycheNuclear Magnetic Resonance ImagingObservation researchObservation studyObservational StudyObservational researchPainPainfulParticipantPatientsPhysiopathologyPregn-4-ene-3,20-dionePregnenedionePrevalenceProgesteronePsychological Well BeingPsychosocial InfluencesPsychosocial IssuesPubertyReceptor ProteinRegimenReportingResearchRestRoleSense of well-beingSensorySeveritiesSex HormonesSex Steroid HormonesSignal TransductionSignal Transduction SystemsSignalingSleepStress HeadacheStructureSymptomsSystematicsTension HeadacheTension-Type HeadacheTestingTestosteroneTherapeutic AndrogenTherapeutic EstrogenTherapeutic HormoneTherapeutic ProgesteroneTherapeutic TestosteroneTimeTrans-TestosteroneWell in selfWomen's prevalenceZeugmatographyadulthoodandrogen inhibitorandrogenicantinociceptionantinociceptivebehavior influencebehavioral influencebiologicbiological signal transductionbrain MR imagingbrain MRIbrain magnetic resonance imagingcentral nervous system processingcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingchronic painclinical decision-makingcomparing females and malescomparing women and mendevelopmentaleffective therapyeffective treatmentemotional wellbeingemotional wellnessexperiencefMRIfemale prevalencefemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesfibromyalgia syndromegonadal steroidshormone therapyimprovedindividualized clinical decisionindividualized decisioninterestlongitudinal designlongitudinal experimental designlongitudinal research designlongitudinal study designmalemental well-beingmental wellbeingmental wellnessmyofascial pain dysfunction syndromeneural imagingneuro-imagingneurobiologicalneuroimagingneurological imagingneurophysiologicalneurophysiologynociceptivenociceptive responseobservational cohort studypain outcomepain processingpain reductionpain sensitivitypain symptompain-related outcomepainful symptompathophysiologypersonalized clinical decisionpersonalized data-driven decisionpersonalized decisionprevalence among femalesprevalence among womenprevalence in femalesprevalence in womenprevalent among femalesprevalent among womenprevalent in femalesprevalent in womenpreventpreventingprospectiveprotective effectpsychological wellbeingpsychological wellnessreceptorreduce painself wellnesssense of wellbeingsex steroidsocial roletreatment strategywomen compared to menwomen compared with menwomen versus menwomen vs. men♀♂
Description preview
Chronic pain syndromes are reported to occur approximately 1.5–2 times more frequently in biological females compared to males after puberty. This disparity may be related to differences in endogenous sex hormone levels, hormone receptor activity, or other biological mechanisms. Exogenous hormone therapy (EHT), including testosterone, estrogen,…
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