grant
"Outside-in” Model of Cardiac Pacemaking: Extracellular Mediated Automaticity
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 15 Jul 2025Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAction PotentialsArtificial PacemakerArtificial cardiac pacemakerAutomobile DrivingBindingBiologicalBiophysical ProcessBiophysicsBody TissuesBrainBrain Nervous SystemCardiacCationsCell BodyCell Communication and SignalingCell SignalingCell membraneCell-Extracellular MatrixCellsCellular MatrixChargeClinicalCommunicating JunctionComplexComputer ModelsComputer SimulationComputer based SimulationComputerized ModelsConsensusCoupledCyclicityCytoplasmic MembraneCytoskeletal SystemCytoskeletonDataDevicesDiffusionDisease ProgressionDysfunctionECMEmbryoEmbryonicEncephalonEnsureExperimental ModelsExtracellular MatrixFormulationFunctional disorderFutureGap JunctionsGenerationsGeometryHeartHumanInterventionIntracellular Communication and SignalingIon ExchangeIonsK elementLifeLinkLiteratureLow-resistance JunctionMediatingMembraneMembrane PotentialsModelingModern ManMolecularMolecular InteractionMorbidityMorbidity - disease rateMyocardial depressionMyocardial dysfunctionNexus JunctionOperative ProceduresOperative Surgical ProceduresPace StimulatorsPacemakersPatientsPeriodicityPhysiopathologyPlasma MembranePopulationPotassiumProcessProteoglycanRegulationResting PotentialsRhythmicityRoleS-A NodeSA node dysfunctionSick Sinus SyndromeSignal TransductionSignal Transduction SystemsSignalingSino-Atrial NodeSinoatrial NodeSinu-Atrial NodeSinuatrial NodeSortingSurgicalSurgical InterventionsSurgical ProcedureTestingTimeTissue constructsTissuesTranslatingTransmembrane Potentialsbehavior influencebehavioral influencebioelectricbioelectricitybiologicbiological signal transductionbiophysical foundationbiophysical mechanismbiophysical principlesbiophysical sciencescardiac dysfunctioncardiac pacemaker cellcomputational modelingcomputational modelscomputational simulationcomputer based modelscomputer based predictioncomputerized modelingcomputerized simulationdesigndesigningdiffuseddiffusesdiffusingdiffusionsdrivingextracellularhealth care burdenheart dysfunctionimplantationin silicoin vivoinsightinterstitialintracellular skeletonion dynamicsmembrane structuremortalitynanonano-architecturenanoarchitecturenew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnodal myocytenovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpacemaker cellpathophysiologyperineuralplasmalemmapredictive modelingrestorationsenescent cellsinoatrial node dysfunctionsinus nodesinus node dysfunctionsocial rolesurgerytheoriesthree dimensionaltissue fixingtissue preparationvoltage
Description preview
Abstract
The heart’s native pacemaker complex, the sinoatrial node (SAN), is a multicellular bioelectric signaling center
responsible for rhythmically initiating the impulses that drive cardiac contraction. SAN dysfunction is extremely
prevalent in humans and represents one of the leading causes for the surgical implantation of artificial pacing…
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