grant
Osteoclast to Osteocyte Crosstalk in Accelerated Bone Turnover
NIHUS FederalResearch GrantFY20252-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acidAblationAbscissionAccelerationActive Follow-upAdoptedAffectAmericanBiologyBisphosphonatesBody TissuesBone DiseasesBone ResorptionBone remodelingBone-Derived Transforming Growth FactorCalcifiedCalciumCell BodyCell Communication and SignalingCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCell-Extracellular MatrixCellsCommunicationCorynebacterium Diphtheriae ToxinCouplesCouplingDataDedicationsDevelopmentDevelopment PlansDevelopment and ResearchDiffusionDiphtheria ToxinDiseaseDisorderECMEndocrine Gland SecretionEnvironmentExcisionExpression ProfilingExtirpationExtracellular MatrixFundingGene ExpressionGene TranscriptionGene set enrichment analysisGenesGeneticGenetic TranscriptionGoalsHormonesHypercalcemic Hormone of MalignancyImageIntermediary MetabolismIntracellular Communication and SignalingInvestigatorsKnowledgeLaboratoriesLactationLigandsMeasuresMediatingMedicalMenopauseMentorsMentorshipMetabolic Bone DiseasesMetabolic ProcessesMetabolismMiceMice MammalsMilk Growth FactorMineralsModelingMolecularMurineMusNational Institutes of HealthNon-Polyadenylated RNANuclearNulliparasNulliparityNulliparousOCIF proteinOPG proteinOsmosisOsteoclastic Bone LossOsteoclastsOsteocytesOsteolysisOsteoporosisPTH Like Tumor FactorPTH-Like ProteinPTH-Related PeptidePTHrPParathyroid Hormone Like Tumor FactorParathyroid Hormone-Like HormoneParathyroid Hormone-Like ProteinParathyroid Hormone-Related PeptidePathologicPathway interactionsPhenotypePhysiciansPhysiologicPhysiologicalPlatelet Transforming Growth FactorProcessProductionProgram DevelopmentPublicationsPumpR & DR&DRNARNA ExpressionRNA Gene ProductsRNA SeqRNA sequencingRNAseqReceptor InhibitionReceptor ProteinRecombinant Parathyroid Hormone-Related ProteinRegulationRemovalReporterReportingReproductionResearchResearch PersonnelResearchersResolutionRibonucleic AcidRoleSamplingScientific PublicationScientistSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSurgical RemovalTGF BTGF-betaTGF-βTGFbetaTGFβTNFRSF11B gene productTestingTherapeutic HormoneTissuesTrainingTraining ProgramsTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransgenic MiceTumor Hypercalcemic FactorTumor Necrosis Factor Receptor Superfamily Member 11BTumor necrosis factor receptor 11bUnited States National Institutes of HealthUniversitiesWorkZoledronic Acidactive followupbiological signal transductionbiphosphonatebisphosphonatebonebone cellbone disorderbone lossbone metabolismbone metabolism disorderbone resorption factorbone turnovercalcificationcareer developmentcell typedensitydesigndesigningdevelopmentaldifferential expressiondifferentially expresseddiffuseddiffusesdiffusingdiffusionsdiphosphonateexperienceexperimentexperimental researchexperimental studyexperimentsextracellularfollow upfollow-upfollowed upfollowupimaginginhibitorinsightintercellular communicationlactatinglactationalmetabolic bone diseasemetabolic bone disordermouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetopg gene productosteoclastogenesis inhibitory factorosteoprotegerinparathyroid hormone-related proteinpathwayprogramsprotein expressionreceptorrelease factorreproductiveresearch and developmentresectionresolutionsresponseskill acquisitionskill developmentsocial roletimelinetooltranscriptional differencestranscriptome sequencingtranscriptomic sequencing
Description preview
PROJECT SUMMARY/ABSTRACT
This proposal comprises a five-year research and career development program for Dr. Diana Athonvarangkul to
achieve independence as an investigator in disorders of bone and mineral metabolism. Dr. Athonvarangkul is a
physician-scientist who completed her training in an NIH-sponsored Medical Scientist Training Program. The…
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