grant
Origin and maturation of protective memory B cell responses against pathogenic viruses in natural infections and upon vaccination.
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY202519S Gamma GlobulinAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAnti-viral ResponseAntibodiesAntibody RepertoireAntibody-Dependent EnhancementAntigensAreaArthropod VectorsB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBinding ProteinsBiological AgentBiological ProductsBiomedical ResearchBirth DefectsBlood Plasma CellBreakbone Fever VirusCase StudyCharacteristicsClinical EvaluationClinical TestingClinical TrialsClonal ExpansionCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationDENVDENV infectionDengueDengue InfectionDengue VirusDengue fever virusDengue virus infectionDevelopmentEvolutionFetomaternal TransmissionFlavivirusFlavivirus InfectionsGeneralized GrowthGestationGoalsGrippeGroup B ArbovirusGrowthHCVHCV diseaseHIVHIV-1HIV-IHIV1HealthHepatitis CHepatitis C virusHepatitis, Viral, Non-A, Non-B, Parenterally-TransmittedHepatitus CHistoryHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1IgMImmuneImmune responseImmune systemImmunesImmunityImmunizationImmunobiologyImmunoglobulin MImmunophysiologyInfantInfectionInfluenzaInfluenza VirusInterventionInvestigationLAV-HTLV-IIILigand Binding ProteinLigand Binding Protein GeneLymphadenopathy-Associated VirusMaternal-Fetal TransmissionMemoryMemory B CellMemory B-LymphocyteMicrocephalyModelingModern ManMutateNHP modelsNational Institutes of HealthOrthoflavivirusPlasma CellsPlasmacytesPregnancyPreventionProtein BindingRecording of previous eventsRegimenResearchSamplingSerotypingSiteTherapeuticTissue GrowthTranslatingTranslationsTransmissionUnited States National Institutes of HealthVaccinationVertical TransmissionViralViral DiseasesVirusVirus DiseasesVirus-HIVZIKAZIKVZIKV infectedZIKV infectionZIKV positiveZika VirusZika virus infectionbiologicsbiopharmaceuticalbiotherapeutic agentbound proteinburden of diseaseburden of illnesscase reportclinical testcongenital zika syndromecongenital zika virus syndromecongenital zikv syndromecross reactivitydengue viral infectiondevelopmentaldisease burdenexperiencehep ChepChepatitis non A non Bhistorieshost responsehuman pathogenimmune system responseimmunogenimmunogenicityimmunoresponsein utero transmissioninfected with ZIKVinfected with zikainfluenzavirusinformation gatheringinnovateinnovationinnovativematernal to fetal transmissionmicrencephalymicroencephalyneutralizing antibodyneutralizing mAbneutralizing monoclonal antibodiesnon A, non B hepatitisnon-A, non-B hepatitisnonhuman primate modelsontogenypan influenza vaccinepan influenza viral vaccinepan influenza virus vaccinepathogenpathogenic virusplasmocyteprogramsprototyperesearch clinical testingresponsesmall moleculetranslationtranslational goaltranslational missiontranslational studytransmission during pregnancytransmission processuniversal flu vaccineuniversal influenza vaccineuniversal influenza virus vaccineuniversal vaccine against fluuniversal vaccine against influenzavaccine candidateviral hepatitis Cviral infectionviral pathogenvirus infectionvirus pathogenvirus-induced diseasezika infectedzika infectionzika viral infectionzikav
Description preview
The human immune system generates a diverse repertoire of pathogen-binding proteins called antibodies secreted by terminally differentiated short- and long-lived plasma cells as well as antigen-experienced B cells which constitute a pool of memory B cells that can further mature upon re-engagement in recall responses. The activity of the TIU is…
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