grant
Organoids Core
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 16 Mar 2018Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AdoptionApplications GrantsBiochemicalBiologic CharacteristicBiologic ModelsBiological CharacteristicsBiological ModelsBody TissuesBreastCOBRECRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancersCas nuclease technologyCell Communication and SignalingCell SignalingCenter of Biomedical Research ExcellenceCenters of Research ExcellenceClinical DataClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColonCommunitiesDevelopmentDiseaseDisorderDrug TargetingDrug resistanceDrugsEngraftmentFundingGenetic TechnicsGenetic TechniquesGoalsGrant ProposalsHealthHeterogeneityHeterograftHeterologous TransplantationHistologicHistologicallyIRBIRBsIn SituIn VitroIn vivo analysisIndividualInfrastructureInstitutional Review BoardsIntracellular Communication and SignalingInvestigatorsKnock-outKnockoutLaboratoriesLiverMalignant NeoplasmsMalignant TumorMediatingMedicationMiceMice MammalsModel SystemModelingMolecularMolecular TargetMorphologyMurineMusNebraskaNormal TissueNormal tissue morphologyOrganoidsPancreasPancreaticPatientsPharmaceutical PreparationsPhasePhysiologicPhysiologicalProstateProstate GlandProstatic GlandProtocolProtocols documentationPublicationsR-Series Research ProjectsR01 MechanismR01 ProgramReagentRectumResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearch SubjectsResearch SupportResearchersResistance profileResistant profileResourcesScientific PublicationSignal TransductionSignal Transduction SystemsSignalingSiteSmall IntestinesStructureSystemTechniquesTechnologyTestingTimeTissuesToxicity TestingToxicity TestsTrainingTransfectionTumor TissueValidationXenograftXenograft procedureXenotransplantationbiobankbiological signal transductionbiorepositorycell typeconventional therapyconventional treatmentdepositorydesigndesigningdevelopmentaldrug detectiondrug resistantdrug sensitivitydrug testingdrug/agentexperienceexperimentexperimental researchexperimental studyexperimentsgene manipulationgenetic manipulationgenetically manipulategenetically perturbhepatic body systemhepatic organ systemin vivoin vivo evaluationin vivo testingmalignancymouse modelmurine modelneoplasm/canceroverexpressoverexpressionrepositoryresistance to Drugresistant to DrugresponseshRNAshort hairpin RNAsmall bowelsmall hairpin RNAsuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttumorvalidationsxeno-transplantxeno-transplantation
Description preview
Project Summary: Organoids Core
Multiple studies support the ability of organoids to faithfully retain the biological characteristics of the tissues from
which they are derived, thus offering a unique system for molecular target discovery and development.
Importantly, patient-derived organoids (PDOs) retain the drug responses seen in the original…
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