grant
Orexinergic system and Circadian Rhythm Disruption
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldAdolescentAdolescent YouthAdultAdult HumanAffectAgeAnochlesiaAnxietyArousalArrhythmiaBehavioralBiochemicalBiochemical ProcessBiological MarkersBlood PlasmaCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCardiac ArrhythmiaCatalepsyCell Communication and SignalingCell PhoneCell SignalingCellular PhoneCellular TelephoneChildChild YouthChildren (0-21)Circadian Rhythm DisorderCircadian RhythmsComputersCoupledDarknessDefectDiet HabitsDietary HabitsDopamineDysfunctionElectroretinographyEnvironmental FactorEnvironmental Risk FactorExposure toFunctional disorderGelineau SyndromeHcrt proteinHcrt/ORXHcrt2 proteinHcrts/ORXsHealthHeart ArrhythmiasHourHumanHydroxytyramineHypothalamic structureHypothalamusInstructionIntracellular Communication and SignalingKnowledgeLateralLifeLightLinkMeasurementMediatingMelatoninMessenger RNAMiceMice MammalsMissionMobile PhonesModern ManModernizationMolecularMurineMusNarcolepsyNarcoleptic SyndromeNational Eye InstituteNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropeptidesNyctohemeral RhythmOutcomeOutcome StudyOutputPace StimulatorsPacemakersParoxysmal SleepPerceptionPhenotypePhotoradiationPhotosensitiveness due to sunPhotosensitivityPhysiologicPhysiologicalPhysiopathologyPlasmaPlasma SerumPlayProcessPublic HealthPupil light reflexReceptor ProteinReportingResearchResearch SupportReticuloendothelial System, Serum, PlasmaRetinaRetinal Ganglion CellsRoleRunningSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSchoolsSedentary behaviorSedentary life-styleServicesSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSightSignal TransductionSignal Transduction SystemsSignalingSleep DeprivationSleep Wake CycleStructureSystemTestingTwenty-Four Hour RhythmVisionVision DisordersVisual AcuityVisual DisorderVisual FieldsWakefulnessWorkaddictionaddictive disorderadolescent healthadult youthadulthoodagesbio-markersbiologic markerbiological signal transductionbiomarkercandidate biomarkercandidate markercell typecircadiancircadian processcircadian rhythmicitycoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemicdaily biorhythmdeficient sleepeating habitelectroretinogramenvironmental riskexposure to lightexposure to visible lighteye fieldgangliocyteganglion cellglobal gene expressionglobal transcription profilehypocretinhypocretin 2hypocretin/orexinhypocretins/orexinshypothalamiciPhoneinadequate sleepinsightinsufficient sleepjuvenilejuvenile humankidslight emissionlight exposurelight pollution exposuremRNAmelanopsinneuronalolder adultolder adulthoodorexinorexin Aorexin Boverexpressoverexpressionpathophysiologypromoterpromotorprotective effectpupillary light reflexpupillary reflexreceptorretinal ganglionscreen timesedentary lifestylesevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsleep debtsleep deficiencysleep deficitsleep insufficiencysleep losssleep to wake transitionsleep to wakefulness transitionsleep wakefulness cyclesleep/wake transitionssmart devicesmart phonesmartphonesocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssun sensitivitysuprachiasmatic nucleustelevision watchingtranscriptometv watchingvisual functionyoung adultyoung adult ageyoung adulthoodyoungster
Description preview
Project Summary
Circadian rhythms play a crucial role in maintaining normal physiological functions. However, modern challenges
disrupt this finely tuned system, leading to circadian rhythm disruption (CRD) and affecting overall health.
Excessive exposure to artificial light, particularly blue light from smart devices, triggers a distinct…
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