grant
Orexin (hypocretin) signaling in ventral tegmental area as a common mediator of sleep disturbances and drug demand in cocaine abstinence
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 15 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AbstinenceArousalBehaviorBindingBrainBrain Nervous SystemCell Communication and SignalingCell CountCell NumberCell SignalingChronicClinical ManagementCocaineCocaine use disorderCommon Rat StrainsDataDevelopmentDoseDrug usageDrugsEEGElectroencephalogramElectroencephalographyElectromyographyEncephalonEventExhibitsFDA approvedFiberFutureGeneticGoalsHcrt proteinHcrt/ORXHcrtr2 gene productHcrts/ORXsHypothalamic structureHypothalamusInsomniaInsomnia DisorderIntracellular Communication and SignalingLateralLinkLiteratureMeasuresMediatingMediatorMedicationMolecular InteractionMotivationNIDANREMNational Institute of Drug AbuseNational Institute on Drug AbuseNerve CellsNerve UnitNeural CellNeurobiologyNeurocyteNeuronsNeuropeptidesOutcomePharmaceutical PreparationsPhenotypePhotometryPopulationPrediction of Response to TherapyRatRats MammalsRattusReceptor ProteinRegulationRelapseReportingRewardsRoleScheduleSignal TransductionSignal Transduction SystemsSignalingSiteSleepSleep ArchitectureSleep disturbancesSleeplessnessSystemTestingTherapeuticTimeTrainingTreatment PeriodTreatment ProtocolsTreatment RegimenTreatment ScheduleVentral Tegmental AreaWakefulnessWorkaberrant sleepaddictionaddictive disorderantagonismantagonistbehavioral economicsbiological signal transductioncocaine relapsecocaine self-administrationdevelopmentaldisrupted sleepdisturbed sleepdrug usedrug/agentexperimentexperimental researchexperimental studyexperimentsgenetic approachgenetic strategyhcrt receptor 2hctr2hypocretinhypocretin receptor 2 gene producthypocretin-2 receptorhypocretin/orexinhypocretins/orexinshypothalamicimpaired sleepimprovement on sleepirregular sleepneurobiologicalneuronalnew approachesnon rapid eye movementnon-REMnon-rapid eye movementnonREMnonrapid eye movementnovelnovel approachesnovel strategiesnovel strategyoresin receptor 2orexinorexin 1 receptororexin B receptororexin receptor 2poor sleeppredict therapeutic responsepredict therapy responsepreventpreventingreceptorrelapse against cocainerelapse predictionreturn to useself-administer cocainesensorsleep disruptionsleep dysregulationsleep improvementsleep/wake disruptionsleep/wake disturbancesocial roletherapy predictiontreatment daystreatment durationtreatment predictiontreatment response predictionventral tegmentumvirtual
Description preview
Summary/Abstract: Initial cocaine abstinence is associated with severe sleep disturbances. Poor sleep is one
of the strongest predictors of return to use (relapse), suggesting potential overlap in brain arousal and reward
networks. Separate literatures link orexin (hypocretin) neurons in lateral hypothalamus (LH) to the regulation of
wake and drug…
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