grant
Orchestrating Tendon Regeneration through Nanoparticle Drug Delivery
Organization UNIVERSITY OF OREGONLocation EUGENE, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202521+ years oldAcPase VAcuteAddressAdultAdult HumanAffectAffinityAntigenic DeterminantsArticular Range of MotionBenchmarkingBest Practice AnalysisBeta Cadherin-Associated ProteinBeta-1 CateninBindingBinding DeterminantsBiodistributionBiological MarkersBody TissuesCUL-2Cell BodyCell-Extracellular MatrixCellsCicatrixDataDepositDepositionDrug DeliveryDrug Delivery SystemsDrug TherapyDrugsECMEpitopesExhibitsExtracellular MatrixFOLHFOLH1FOLH1 geneFailureFibroblastsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFolate Hydrolase 1FrequenciesFunctional impairmentGCP2GenesGlutamate Carboxypeptidase IIHPLCHigh Performance Liquid ChromatographyHigh Pressure Liquid ChromatographyHigh Speed Liquid ChromatographyImmunofluorescenceImmunofluorescence ImmunologicImmunoglobulin Enhancer-Binding ProteinImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentIn VitroInflammatoryInjuryInterventionJoint Range of MotionLigandsMacrophageMaleic AnhydrideMechanicsMediatingMedicationModelingMolecular InteractionMorphologyMφN-Acetylated Alpha-Linked Acidic Dipeptidase 1NAALAD1NAALADase INF-kBNF-kappa BNF-kappaBNFKBNatural regenerationNuclear Factor kappa BNuclear Transcription Factor NF-kBPRO2286PSMPSMAPeptidesPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhenotypeProceduresProcessProductionProstate-Specific Membrane AntigenRecoveryRecovery of FunctionRegenerationResolutionScarsSignal PathwaySiteSpecificityStyrenesSystemTRAP type 5 AcPaseTRAcPTendon InjuriesTendon structureTendonsTestingTherapeuticTissuesToxic effectToxicitiesTranscription Factor NF-kBWorkacid phosphatase Vadulthoodagedaged miceaged mousebenchmarkbeta catbeta cateninbio-markersbiologic markerbiomarkercellular targetingdesigndesigningdetermine efficacydrug candidatedrug interventiondrug release kineticsdrug release ratedrug treatmentdrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationelderly miceevaluate efficacyexamine efficacyexperimentexperimental researchexperimental studyexperimentsflow cytophotometryfunctional recoveryfunctional restorationhealingimaging in vivoimprovedin vivoin vivo imaginginjuriesinnovateinnovationinnovativekappa B Enhancer Binding Proteinmechanicmechanicalminimally invasivenano particlenano particle deliverynano-sized particlenanoparticlenanoparticle deliverednanoparticle deliverynanoparticle drugnanosized particlenovelnuclear factor kappa betaold micepharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingrange of motionregenerateregenerativeregenerative approachregenerative strategyregenerative techniquerepairrepairedresolutionsresponserestore functionrestore functionalityrestore lost functionscRNA sequencingscRNA-seqside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsite targeted deliveryspatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial temporalspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporaltargeted deliverytartrate-resistant acid phosphatasetechnology platformtechnology systemtranscriptome profilingtranscriptomic profilingtype 5 acid phosphataseβ-catenin
Description preview
Project Summary
Tendon regeneration following acute injury is marred by a fibrotic healing response that impairs complete
functional recovery. Despite the frequency of injuries and complications associated with poor healing, including
re-injury and limited range of motion, no pharmacological approaches exist to improve tendon healing. While…
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