grant
Options for Delivery of Short-Course Tuberculosis Preventive Therapy: The 3HP Options Trial
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Aug 2018Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusAIDS/HIVAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAddressAdherenceAdoptionAdverse ExperienceAdverse eventAfricaBudgetsCause of DeathCharacteristicsClinicCluster randomization trialCluster randomized trialConsolidated Framework for Implementation ResearchConsolidated Framework for Implementation ScienceConsolidated Framework for Implementing ChangeCounselingDataDirectly Observed TherapyDoseDrugsEffectivenessEvaluationFeedbackFundingGeographyHIVHIV/AIDSHealthHealth Care FacilityHealth Care SystemsHealth FacilitiesHealth systemHuman Immunodeficiency VirusesIncidenceInfrastructureInterventionInterviewInvestmentsIsonicotinic Acid HydrazideLAV-HTLV-IIILymphadenopathy-Associated VirusM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMaintenanceMedicationMethodsMonitorMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNHLBINational Heart, Lung, and Blood InstituteParticipantPersonsPharmaceutical PreparationsPhonePolicy MakerPopulationPreventative therapyPreventionPreventive therapyRE-AIMRandomization trialRandomizedReach, Effectiveness, Adoption, Implementation, and MaintenanceRegimenReportingResearchResearch ResourcesResourcesRuralSafetySamplingSelf AdministeredSelf AdministrationSerious Adverse EventServicesSevere Adverse EventTB infectionTechnologyTelephoneTestingTextTuberculosisUgandaUrineVirus-HIVVisitVoiceWorkbarriers to implementationbudget impactcare facilitiescompare effectivenesscostcost effectivecost effectivenesscost estimatecost estimationdigitaldisseminated TBdisseminated tuberculosisdrug/agenteffectiveness/implementation hybrid studyeffectiveness/implementation studyexperienceimplementation barriersimplementation challengesimplementation costimplementation facilitationimplementation investmentimprovedincremental costincremental cost-effectivenessincrementally cost effectiveinfection due to Mycobacterium tuberculosisisoniazidnon-drugnondrugperi-urbanperiurbanperson centeredpreventpreventingprimary outcomeprogramsrandomisationrandomizationrandomized trialrandomly assignedreach, efficacy, adoption, implementation, and maintenancerelative costrelative costsresponserifapentinescale upserious adverse experienceserious adverse reactionside effectsuccesstrial designtuberculosis infectiontuberculous spondyloarthropathyurban areaurban locationurban region
Description preview
PROJECT SUMMARY/ABSTRACT
Tuberculosis preventive therapy (TPT) is known to reduce the incidence of tuberculosis (TB) among people
living with HIV (PLHIV) and is considered a core service of National AIDS Programs. TPT coverage has been
steadily increasing with the availability of short-course regimens such as 12 weeks of once-weekly isoniazid-…
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