grant
OPTIMUM OB-TXA: Optimal TIMing, route and dose of tranexamic acid prior to UMbilical cord clamp for postpartum hemorrhage prevention
Organization INOVA HEALTH CARE SERVICESLocation Fairfax, UNITED STATESPosted 9 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20250-11 years old0-4 weeks oldAMCAAMCHAAT III-protease complexAbdominal DeliveryAddressAdoptionAdvocateAffectAntifibrinolysinsAntifibrinolytic AgentsAntifibrinolyticsApproaches to preventionBiological MarkersBiometricsBiometryBiostatisticsBirthBleedingBlood TransfusionBreast MilkBreastmilkC sectionCesareanCesarean sectionCessation of lifeChildChild YouthChildbirthChildren (0-21)CirculationClampingsClinicalClinical PharmacologyClinical SciencesClinical TrialsClosure by clampClottingCoagulationCoagulation ProcessCommunitiesCord BloodD-dimerD-dimer fibrinD-dimer fragmentsDataDeathDiscipline of obstetricsDisparitiesDisparityDoseDrug KineticsDrug TherapyDrugsEnvironmentEpidemiologyEquilibriumEventExclusionExposure toFibrinFibrin fragment DFibrinolytic TherapyGeneric DrugsGestationGoalsGrantHemorrhageHemostasisHemostatic AgentsHemostatic functionHemostaticsHigh Risk WomanHospitalsHuman MilkHuman Mother's MilkIV InfusionIV bolusImprove AccessInfusionInfusion proceduresInternationalIntramuscularIntramuscular InjectionsIntravenousIntravenous BolusIntravenous infusion proceduresKnowledgeLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMammary Gland MilkMarylandMaternal MortalityMaternal-fetal medicineMeasuresMedicationMedicineMethodsMorbid ObesityMother's MilkNatureNausea and VomitingNeonatalNewborn InfantNewbornsNon-proprietary DrugsNonproprietary DrugsNorth CarolinaObesityObstetricsOperative ProceduresOperative Surgical ProceduresOutcomeOutcome StudyPK/PDParturitionPatientsPerinatalPeripartumPharmaceutical PreparationsPharmacokineticsPharmacological TreatmentPharmacotherapyPopulationPost-partum HemorrhagePostpartum HemorrhagePostpartum PeriodPregnancyPregnant WomenPrevalencePreventionPrevention approachProceduresProphylactic treatmentProphylaxisRandomizedReportingResearchResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingRiskRisk AssessmentRoleRouteSafetySample SizeSamplingSevere obesitySiteSubgroupSurgicalSurgical InterventionsSurgical ProcedureTestingTherapeuticTherapeutic ThrombolysisThrombin-Antithrombin ComplexThrombolytic TherapyThrombosisTranexamic AcidTranslational ResearchTranslational ScienceTraumaUmbilical CordUmbilical Cord BloodUmbilical RegionUmbilical cord structureUmbilicusUnited StatesUniversitiesVaginaVaginal deliveryVaginal delivery procedureWomanWorkadiposityantithrombin III-protease complexat-risk femalesat-risk womenbalancebalance functionbio-markersbiologic markerbiomarkerblood losschild birthcohortcorpulencedeliver vaginallydrug interventiondrug treatmentdrug/agentepidemiologicepidemiologicalexpectant motherexpectant womenexpecting motherexpecting womenexperienceextreme obesityfallsfemales at high riskfetalfetal cord bloodfibrin fragment D-dimerfibrin fragment D1 dimerfibrin fragment DDhigh risk femalesimprovedindividuals who are pregnantinfusionsinnovateinnovationinnovativeintramuscular drug administrationintravenous administrationintravenous infusionkidsmaternal deathmaternal milkmaternal morbiditymaternal riskmaternal safetymembermultidisciplinaryneonatal exposurenew approachesnewborn childnewborn childrennovel approachesnovel strategiesnovel strategypeople who are pregnantpharmaceutical interventionpharmacodynamic modelpharmacokinetics and pharmacodynamicspharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacometricspharmacotherapeuticsplacental transferpost-partumpregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingprophylacticrandomisationrandomizationrandomly assignedside effectsocial rolespecial interest groupsurgeryt-AMCHAthose who are pregnantthrombin-antithrombin III complexthromboticthrombotic diseasethrombotic disordertranslation researchtranslational investigationtranslational medicinewomen at high riskwomen who are pregnantyoungster
Description preview
Project Summary
The primary goal of this proposal is to fill critical gaps related to timing, route and dose of tranexamic acid (TXA)
in prevention of postpartum hemorrhage (PPH) to maximize maternal benefit while minimizing fetal-neonatal and
maternal risks. With my clinical background in Maternal-Fetal Medicine, research experiences in…
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