grant
Optimizing the diagnostic approach to cephalosporin allergy testing (DACAT Trial)
Organization MAYO CLINIC JACKSONVILLELocation JACKSONVILLE, UNITED STATESPosted 10 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20267S Gamma GlobulinAccuracy of DiagnosisAddressAllergicAllergic ReactionAllergyAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAntibiotic AgentsAntibiotic DrugsAntibioticsAntibodiesAntigenic DeterminantsBinding DeterminantsBiologicalBiologyCefazolinCephalosporinsCharacteristicsChemicalsClinicalClinical TrialsClinical Trials NetworkCollaborationsCooperative AgreementsDevelopmentDiagnosisDiagnosticDiagnostic testsDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrug AllergyDrug HypersensitivityDrugsEpitopesEvaluationExclusionFutureGoalsHaptensHistoryHospital AdmissionHospitalizationHypersensitivity skin testingIgEIgGImmunoglobulin EImmunoglobulin GIndividualMediatingMedicationMetabolic GlycosylationMiscellaneous AntibioticMolecularMulti-Institutional Clinical TrialMulti-center clinical trialMulti-site clinical trialMulticenter clinical trialMultisite clinical trialNIAIDNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthParentsParticipantPathway interactionsPatientsPatternPenicillin AllergyPenicillinsPerioperativePharmaceutical PreparationsPlacebo ControlPractice GuidelinesPredictive ValueProceduresProcessReactionRecording of previous eventsReportingResearchRiskRoleSensitivity and SpecificitySideSiteSkin TestsSpecialistSpecific qualifier valueSpecificitySpecifiedStructureSubgroupTestingTimeU-Series Cooperative AgreementsUnited StatesUnited States National Institutes of Healthbeta lactam antibioticbeta-Lactamsbiologiccross reactivitydevelopmentaldiagnostic accuracydiagnostic approachdiagnostic strategydrug/agentglycosylationhigh riskhistorieshypersensitivity testimmunologic skin testnovelparentpathwayplacebo controlledprimary outcomerecruitsocial roletooltrial designβ lactam antibioticβ-Lactams
Description preview
PROJECT SUMMARY
In the United States, beta-lactam antibiotics are the leading cause of allergic reactions. Cephalosporin
antibiotics, in particular, are the most common cause of drug-induced anaphylaxis and perioperative allergy.
For penicillin allergy, the mechanism of allergy and the antigenic determinants are known; validated penicillin
skin…
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