grant
Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults with Multiple Chronic Conditions: A Sequential, Multiple Assignment, Randomized Trial
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 15 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202665 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAddressAged 65 and OverAnthropometryArthritisBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBody Weight ChangesBody Weight decreasedCessation of lifeCharacteristicsChronicClinicalClinical TrialsCollaborationsCombined Modality TherapyComplexConditioning TherapyDataDeathDiabetes MellitusDietitianEnrollmentEvaluationEvidence based interventionFutureGeriatricsGoalsHealthHealth Care CostsHealth CostsHealth Insurance for Aged and Disabled, Title 18Health Insurance for Disabled Title 18Health PromotionHealth behavior changeHypertensionIndividualInstitute of MedicineInstitute of Medicine (U.S.)InterventionIntervention StrategiesLicensingLife StyleLifestyleLong-term disabilityMedicalMedicareModelingMotivationMultimodal TherapyMultimodal TreatmentNAS/IOMNational Institute of AgingNational Institute on AgingNational Institutes of HealthNursing HomesNutrition ResearchNutritional StudyObesityOutcomeParticipantPatientsPatternPersonalized medical approachPersonsPhysical FunctionPilot ProjectsPoliciesPositionPositioning AttributePrecision HealthPrecision carePrescribed exercisePrevalenceProblem SolvingQALYQOLQuality of lifeQuality-Adjusted Life ExpectancyQuality-Adjusted Life YearsRandomization trialRandomizedResearchResearch PriorityRiskRisk FactorsSalutogenesisScienceSequential Multiple Assignment Randomized TrialStrategic PlanningTelemedicineTestingTimeTitle 18TrainingUnited States National Institutes of HealthVascular Hypertensive DiseaseVascular Hypertensive DisorderWeightWeight ChangeWeight GainWeight IncreaseWeight LossWeight ReductionWorkabove age 65adaptive interventionadiposityadult adiposityadult obesityadults with obesityadverse consequenceadverse outcomeafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65armarthriticassessing cost effectivenessbehavior interventionbehavioral interventionbody weight gainbody weight increasebody weight lossclinical decision-makingclinical heterogeneityclinical significanceclinically significantcombination therapycombined modality treatmentcombined treatmentcomparative effectiveness trialcorpulencecost effective interventioncost effectivenesscost-effectiveness evaluationcustomized therapycustomized treatmentdecline in functiondecline in functional statusdecrease disabilitydecrease in disabilitydetermine cost effectivenessdetermine efficacydiabetesdiet and exercisedisability reductiondisability riskefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationenrollevaluate cost-effectivenessevaluate efficacyexamine cost effectivenessexamine efficacyexercise prescriptionfunctional declinefunctional status declinegeriatric medicineglobal healthhealth insurance for disabledhealth traininghigh blood pressurehigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhuman old age (65+)hyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedincremental costindexingindividualized approachindividualized careindividualized medicineindividualized patient careindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinnovateinnovationinnovativelessen disabilityminimize disabilitymitigate disabilitymortalitymulti-modal therapymulti-modal treatmentmultimorbiditymultiple chronic conditionsmuscle bulkmuscle formmuscle massnursing homeolder adultolder adulthoodover 65 yearspatient specific therapiespatient specific treatmentpersonalized approachpersonalized carepersonalized patient carephysical therapistphysiotherapistpilot studypilot testpost interventionprecision approachprecision medicineprecision-based medicineprimary care providerprimary outcomepromoting healthproviders from primary careproviders of primary carerandomisationrandomizationrandomized trialrandomly assignedreduction in disabilityremote monitoringresponseresponse to therapyresponse to treatmentsecondary outcomeskillsslow disabilitysuccesstailored approachtailored medical treatmenttailored therapytailored treatmenttelehealththerapeutic responsetherapy responsetreatment responsetreatment responsivenesstreatment strategytrial designunique treatmentweight loss interventionweight loss therapyweight loss treatmentweightswt gainwt-loss≥65 years
Description preview
PROJECT SUMMARY
Consistent with the research priorities of the National Institute on Aging, this R01 application will investigate the
optimal intervention sequence to achieve weight loss in older adults with obesity and ≥ 2 Medicare-defined
multiple chronic conditions (MCC). The growing prevalence of obesity in older adults, particularly in those…
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