grant
Optimizing open placebos for chronic pain patients
Organization RHODE ISLAND HOSPITALLocation PROVIDENCE, UNITED STATESPosted 1 Sept 2018Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202521+ years oldActive Follow-upAdultAdult HumanAdvertisingAmericanBlack BoxCOBRECausalityCell PhoneCellular PhoneCellular TelephoneCenter of Biomedical Research ExcellenceCenters of Research ExcellenceClinicalClinical ResearchClinical StudyClinical TrialsComputersControl GroupsDeceptionDrugsElementsEsthesiaEtiologyHEAL InitiativeHelping End Addiction Long-termHelping to End Addiction Long-termInfumorphInstructionInterventionInvestigatorsKadianMS ContinMSirMeasuresMedicationMeta-AnalysisMobile PhonesModelingMorphiaMorphineNatureOpiatesOpioidOramorphOramorph SROutcomeOutcome StudyOverdosePainPain ControlPain TherapyPain intensityPain interferencePain managementPainfulParticipantPatientsPersonality TraitsPharmaceutical PreparationsPlacebo EffectPlacebosPlayPopulationProviderPublic HealthPublishingQuestionnairesRandomizedResearchResearch PersonnelResearchersRoleRoxanolSensationSham TreatmentStatex SRTeleconferencesTestingUnited StatesVideoconferencingVisualizationWorkactive followupactive methodactive techniqueactive treatmentadulthoodalleviate symptomameliorating symptomarmcare as usualcausationchronic painchronic pain conditionchronic pain controlchronic pain disorderchronic pain interventionchronic pain managementchronic pain patientchronic pain therapychronic pain treatmentchronic painful conditioncompare to controlcomparison controlcostdecrease symptomdesigndesigningdisease causationdrug/agentevidence baseexpectancy effectexpectation effectfewer symptomsfollow upfollow-upfollowed upfollowupiPhoneimprovedlicit opioidmilligrammindfulnessnocebonon-narcotic analgesicnon-opiate analgesicnon-opioidnon-opioid analgesicnon-opioid therapeuticsnonnarcotic analgesicsnonopiate analgesicnonopioidnonopioid analgesicsopen labelopen label studyopiate consumptionopiate crisisopiate deathsopiate drug useopiate intakeopiate medicationopiate mortalityopiate useopioid consumptionopioid crisisopioid deathsopioid drug useopioid epidemicopioid intakeopioid medicationopioid mortalityopioid overdose deathopioid related deathopioid usepain catastrophizingpain interventionpain outcomepain treatmentpain-related outcomeparticipant enrollmentpatient enrollmentpatient with chronic painpillplacebo responseprescribed opiateprescribed opioidprescription opiateprescription opioidprimary outcomerandomisationrandomizationrandomized, clinical trialsrandomly assignedrecruitreduce symptomsrelieves symptomssecondary outcomesham therapysmart phonesmartphonesocial rolesymptom alleviationsymptom reductionsymptom relieftreat chronic paintreatment as usualtreatment effectusual careverbalvideo conferencing
Description preview
PROJECT SUMMARY
The United States is in the midst of a serious opioid epidemic, with 107,622 drug overdose causalities
in 2021. An astounding 1 in 5 Americans have chronic pain, and prescription opioid medication for chronic pain
treatment has more than tripled between 1999 and 2015. Research is needed to develop and test safe
alternatives to…
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