grant
Optimizing methotrexate use for the management of chronic pediatric non-infectious uveitis
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldActive Follow-upAdultAdult HumanAnteriorBiologicalBiological AgentBiological ProductsBiological Response Modifier TherapyBiological TherapyBiometricsBiometryBiostatisticsBlindnessBlood SampleBlood specimenCell BodyCellsChildChild HealthChild YouthChildhoodChildren (0-21)ChronicChronic Childhood ArthritisClinicalCystoid Central Retinal EdemaCystoid Macular EdemaDataDecision MakingDiagnosisDiseaseDisorderDoppler OCTDropsDrugsEnrollmentExpression SignatureExtravasationEye ExamEye ExaminationEye diseasesFailureFluoresceinFluorescein AngiographyGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfileGene Expression ProfilingGene TranscriptionGenetic TranscriptionGlucocorticoidsGoalsImageImaging DeviceImaging InstrumentImaging ToolImmuneImmunesImmunologistImmunologyIndividualInflammationInflammatoryInvestigationJuvenile Chronic ArthritisJuvenile Chronic PolyarthritisJuvenile Rheumatoid ArthritisLaboratoriesLeakageLocationMedicationMethotrexateMethotrexate MethylaminopterinMethotrexatumMetotrexatoModalityMonitorMusculoskeletal Pain DisorderNational Institutes of HealthNomenclatureOCT TomographyOphthalmologistOphthalmologyOptical Coherence TomographyOralOutcomePatient riskPatientsPharmaceutical PreparationsPrediction of Response to TherapyPredictive FactorRNA ExpressionRNA SeqRNA sequencingRNAseqResearchRheumatic DiseasesRheumatismRheumatologic DiseasesRheumatologic DisorderRheumatologyRiskRisk FactorsSafetySightSpillageStandardizationSystemic diseaseTestingTherapeuticTherapeutic EffectTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionUnited States National Institutes of HealthUveitisVisionWhole BloodWorkactive followupadulthoodanalyze gene expressionanterior chamberbiologicbiological therapeuticbiological treatmentbiologically based therapeuticsbiologicsbiopharmaceuticalbiotherapeutic agentbiotherapeuticsbiotherapyclinical examclinical examinationdemographicsdesigndesigningdiscover genesdisease heterogeneitydrug/agenteffective therapyeffective treatmentenrollexperimentexperimental researchexperimental studyexperimentseye disordereye imagingfollow upfollow-upfollowed upfollowupgene discoverygene expression analysisgene expression assaygene expression patterngene expression signaturehigh riskimage-based methodimagingimaging methodimaging modalityimprovedinnovateinnovationinnovativejuvenile arthritisjuvenile idiopathic arthritiskidsocular diseaseocular disorderocular imagingophthalmic examinationophthalmic imagingophthalmopathyoptical Doppler tomographyoptical coherence Doppler tomographypediatricperipheral bloodpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpredict responsivenesspredict therapeutic responsepredict therapy responsepredicting responsepredictive signaturepreventpreventingprospectivequantitative imagingresponseresponse to therapyresponse to treatmentrheumatologiststandard carestandard treatmentsuccesstherapeutic responsetherapy optimizationtherapy predictiontherapy responsetranscriptional profiletranscriptional profilingtranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtranslational studytreatment optimizationtreatment predictiontreatment responsetreatment response predictiontreatment responsivenesstreatment strategyvision lossvisual functionvisual lossyoungster
Description preview
PROJECT SUMMARY
Pediatric chronic non-infectious uveitis (NIU) is an inflammatory ocular disease that has a substantial risk for
sight-threatening complications. Methotrexate (MTX) is the preferred first line systemic treatment for all subtypes
of NIU given its overall safety and affordability. However, MTX failure is as high as 50%. Biologic…
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