grant
Optimizing lipid RVn monophosphate prodrugs to maximize RVn-triphosphate delivery
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 18 Jul 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20251,2,3-Propanetriol1,2,3-Trihydroxypropane2019 novel corona virus2019 novel coronavirus2019-nCoVAbscissionAffectAnti-viral AgentsBioavailabilityBiological AvailabilityBlood PlasmaBlood SerumBody TissuesBreakbone Fever VirusBypassCOVID-19 therapyCOVID-19 treatmentCOVID-19 virusCOVID19 virusCell Culture TechniquesChylomicronsClinicalClinical TreatmentCoV-2CoV2CoronaviridaeCoronavirusDENVDataDengueDengue VirusDengue fever virusDevelopmentDrug KineticsDrug PrecursorsDrug or chemical Tissue DistributionDrugsEC 2.7.7.48EbolaEnzyme GeneEnzyme KineticsEnzymesEster HydrolaseEstersExcisionExtirpationFiloviridaeFilovirusFlavivirusFrankfurt-Marburg Syndrome VirusGS-441524GS-5734GenerationsGeneticGlycerinGlycerolGroup B ArbovirusIn VitroIntermediary MetabolismIntestinalIntestinesKnock-outKnockoutLecithinase CLibrariesLipidsLiverLungLung Respiratory SystemLymphaticLysophospholipidsMarburgMarburg virusMarburg-like VirusesMarburgvirusMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMetabolicMetabolic ProcessesMetabolismMethodsMiceMice MammalsMissionModificationMurineMusNIAIDNational Institute of Allergy and Infectious DiseaseNipahNucleosidesOralOral AdministrationOral Drug AdministrationOrthocoronavirinaeOrthoflavivirusOrthomarburgvirusParamyxoviridaeParamyxovirusPathogenicityPharmaceutical PreparationsPharmacokineticsPhospholipase CPhysiologic AvailabilityPlasmaPlasma SerumPositionPositioning AttributePro-DrugsProdrugsPublic HealthPublishingRNA ReplicaseRNA Virus InfectionsRNA VirusesRNA viral infectionRNA-Dependent RNA PolymeraseRNA-Directed RNA PolymeraseRemovalReticuloendothelial System, Serum, PlasmaSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 therapySARS-CoV-2 treatmentSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SeriesSerumSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SiteSmall IntestinesStructure-Activity RelationshipSurgical RemovalSynthesis ChemistrySynthetic ChemistryTherapeuticThoracic DuctTissue DistributionTissuesVekluryViralViral ActivityViral FunctionViral PhysiologyVirusVirus ReplicationWuhan coronavirusabsorptionanaloganti-viral compoundanti-viral drugsanti-viral efficacyanti-viral medicationanti-viral therapeuticanti-viralsbowelcell culturecell culturescell typechemical structure functionclinical interventionclinical therapycorona viruscoronavirus disease 2019 therapycoronavirus disease 2019 treatmentcoronavirus disease 2019 viruscoronavirus disease-19 virusdesigndesigningdevelopmentaldrug developmentdrug/agentesteraseglobal healthhCoV19hepatic body systemhepatic metabolismhepatic organ systemimprovedin vitro activityin vivoinnovateinnovationinnovativeintraoral drug deliverylipophilicitylipophosphodiesterase Iliver metabolismmouse modelmurine modelnCoV2novelnucleoside monophosphatepandemic concernpandemic potentialpandemic riskpandemic threatphosphatidylcholine cholinephosphohydrolasepre-clinical efficacypreclinical efficacyrational designremdesivirresectionrespiratory virusscaffoldscaffoldingsevere acute respiratory syndrome coronavirus 2 therapysevere acute respiratory syndrome coronavirus 2 treatmentsite targeted deliverysmall bowelstructure function relationshiptargeted deliverytraffickingtreat COVID-19treat SARS-CoV-2treat coronavirus disease 2019treat severe acute respiratory syndrome coronavirus 2trial regimentrial treatmenttriphosphatetripolyphosphateuptakeviral multiplicationviral replicationvirus multiplication
Description preview
PROJECT SUMMARY/ABSTRACT
Emerging RNA viruses, especially respiratory viruses, are among the leading threats to global health. With few
treatments currently available, there is an urgent and ongoing need for the development of safe, effective oral
antivirals. The objective of this application is to optimize an innovative lipid prodrug delivery…
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