grant
Optimizing anti-microbial immunity by targeting Sts-1
Organization STATE UNIVERSITY NEW YORK STONY BROOKLocation STONY BROOK, UNITED STATESPosted 23 Jul 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AccelerationAnimalsAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsAntimicrobial ResistanceBioavailabilityBiologicalBiological AvailabilityBiologyC albicansC. albicansC.albicansCandida albicansCell BodyCellsCheckpoint inhibitorChemosensitizationChemosensitization/PotentiationClinicalDataDeath RateDevelopmentDevelopment and ResearchDiseaseDisorderDrugsEndocarditisEnzyme GeneEnzymesF tularensisF. tularensisFrancisella tularensisGeneticGoalsGram-Positive BacteriaHealthHistoryHost resistanceImmuneImmune RegulatorsImmune checkpoint inhibitorImmune responseImmunesImmunityImmunomodulatorsInfectionInflammationLeadLong-term infectionMacrophageMediatingMedicalMedicationMiceMice MammalsMiscellaneous AntibioticModelingModernizationMurineMusMφOutcomePasteurella tularensisPathogenicityPb elementPharmaceutical PreparationsPhenocopyPhenotypePhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhysiologic AvailabilityPneumoniaPositionPositioning AttributePotentiationProceduresR & DR&DRecording of previous eventsResearch SupportResistanceResistance to infectionRoleS aureusS. aureusS. aureus infectionSepsisSeriesSignal InductionSignal PathwayStaph aureusStaph aureus infectionStaphylococcus aureusStaphylococcus aureus infectionStructureTestingTherapeuticTimeToxic effectToxicitiesVaccinesVirulentWorkacquired drug resistanceanti-bacterialanti-microbialanti-microbial resistantantimicrobialbacteria pathogenbacterial pathogenbiologicblood infectionbloodstream infectionchronic infectiondevelopmentaldrug developmentdrug/agentenzyme activityexperiencefungal pathogenfungi pathogenfungusheavy metal Pbheavy metal leadhistorieshost responseimmune check point inhibitorimmune modulatorsimmune system responseimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimmunoresponseimprovedin vivoinfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureusinfection in the bloodinfection of the bloodinfection resistanceinfectious disease treatmentinhibitorinnate check pointinnate checkpointinnate immune check pointinnate immune checkpointinnate immunity checkpointinnovateinnovationinnovativelead optimizationlead seriesmicrobe pathogenmicrobialmicrobial pathogenmicroorganismmortality ratemortality rationew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathogenpathogenic bacteriapathogenic funguspathogenic microbepersistent infectionresearch and developmentresistance to anti-microbialresistantresistant to antimicrobialresponsesmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial roletherapeutic targettranslational impacttreatment strategy
Description preview
Project Summary
Recent studies have established two homologous phosphatases, Sts-1 and -2, as negative regulators of immune
signaling pathways. Interestingly, mice lacking Sts expression (Sts-/-) are profoundly resistant to infection by a
number of virulent microbial pathogens, including Candida albicans, Staphylococcus aureus, and Francisella…
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