grant
Optimization of lead candidates for an on-demand male contraceptive
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 21 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253,5 cyclic AMP synthetaseAcrosome ReactionAcuteAdenyl CyclaseAdenylate CyclaseAdenylyl CyclaseAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAssayBackBicarbonatesBindingBioassayBioavailabilityBiological AssayBiological AvailabilityBody TissuesCannot achieve a pregnancyCapacitation of SpermatozoaCervixCervix UteriCharacteristicsChronicCirculationContraceptionContraceptive AgentsContraceptive methodsContraceptivesDNA mutationDataDepositDepositionDevelopmentDifficulty conceivingDomestic RabbitDorsumDoseDrug KineticsDrugsEjaculationEpididymisEventExcretory functionFallopian TubesFemaleFertility ControlFertilization in VitroFertilized EggFertilized OvumGene DeletionGeneticGenetic ChangeGenetic defectGenetic mutationGlaucomaGoalsHCO3Half-LifeHourHumanHydrogen CarbonatesIND FilingIND applicationIND packageIND submissionIn VitroInfertilityInhibition of FertilizationInjectionsIntermediary MetabolismIntraocular PressureInvestigational DrugsInvestigational New Drug ApplicationInvestigational New DrugsInvestmentsKO miceKidney CalculiKidney StonesKineticsKnock-outKnock-out MiceKnockoutKnockout MiceLeadLegal patentMale ContraceptionMale Contraceptive AgentsMale ContraceptivesMale InfertilityMammalian OviductsMedicationMedicinal ChemistryMetabolic ProcessesMetabolismMetaphaseMethodsMiceMice MammalsMitotic MetaphaseModern ManMolecularMolecular InteractionMotilityMouse StrainsMurineMusMutationNull MouseOcular TensionOocytesOralOral ContraceptivesOryctolagus cuniculusOvocytesOvulationPartner in relationshipPatentsPathologyPb elementPharmaceutic ChemistryPharmaceutical ChemistryPharmaceutical PreparationsPharmacokineticsPhenotypePhysiologic AvailabilityPhysiologic Intraocular PressurePreclinical TestingPredispositionProcessPropertyProteinsRabbitsRabbits MammalsRenal CalculiRenal StoneResearch ContractsResearch ResourcesResourcesSafetySalpinxSeriesSpermSperm CapacitationSpermatocytesSpermatozoaSpermiocytesSterilitySusceptibilitySwimmingTest-Tube FertilizationTestingTherapeuticTimeTissuesTopical Drug AdministrationTopical applicationTravelUSAIDUterine CervixUterine TubesUterusVaginaVaginal RingVaginal deliveryVaginal delivery procedureabsorptionacrosomal reactionapply topicallyappropriate dosebirth control pillclinical developmentcontraceptive efficacydeliver topicallydeliver vaginallydesigndesigningdevelopmentaldrug developmentdrug standarddrug/agentefficacy studyexcretionexperimentexperimental researchexperimental studyexperimentsfemale genital tractfemale reproductive tractfertility cessationfertility lossfocus on malefocused on mengene deletion mutationgenome mutationglaucomatousheavy metal Pbheavy metal leadin vivoinfertileinfertile malesinfertile meninfertility in meninhibitorinnovateinnovationinnovativeintra-ocular pressureintravaginal ringknockout genelead candidatelead optimizationmalemale antifertility drugmale factor infertilitymale fertilitymale focusedmale germ cellsmale specificmale targetedmatemenmen facing infertilitymen with infertilitymodel of animalnoveloptimal drug dosageoptimal drug doseoviductpharmacologicpre-clinicalpre-clinical developmentpre-clinical testingpreclinicalpreclinical developmentpreventpreventingresidenceresidential buildingresidential siteside effectsmall molecular inhibitorsmall molecule inhibitorsperm cellsperm functionsteriletargeted to mentheoriestopical administrationtopical deliverytopical drug applicationtopical drug deliverytopical instillationtopical treatmenttreat topicallywombwomen's genital tractwomen's reproductive tractzoospermzygote♀♂
Description preview
Mammalian sperm are stored in the epididymis in a dormant state; they are immotile and unable
to fertilize the egg. Upon ejaculation, sperm begin swimming and initiate a process called
capacitation, where they become competent to fertilize. An initial event in capacitation and
activation of motility is the HCO3- induced stimulation of soluble…
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