grant
Optimization of High Frequency Irreversible Electroporation (H-FIRE) for tumor ablation and immune system activation in pancreatic cancer applications
Organization VIRGINIA POLYTECHNIC INST AND ST UNIVLocation BLACKSBURG, UNITED STATESPosted 10 May 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AblationAddressAfter CareAfter-TreatmentAftercareAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesApoptosisApoptosis PathwayBiophysicsBlood VesselsBody TissuesCancer cell lineCancersCell DeathCell membraneCessation of lifeChemotherapy and RadiationChemotherapy and/or radiationClinicalClinical ResearchClinical StudyClinical TrialsComplicationCyclic AnalysesCyclic AnalysisCytoplasmic MembraneDataDeathDefectDevelopmentDiagnosisDiameterDiseaseDisorderDistalDuctDuct (organ) structureElectrical ImpedanceElectrodesElectroporationElementsFamily suidaeFeedbackFourier AnalysisFrequenciesFutureGeometryHeterogeneityHumanImmune responseImmune systemImmunocompetentImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologyImmunosuppressed HostImpedanceIn SituInjuryInterphaseIntratumoral heterogeneityLocationMalignant CellMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMediatingMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMiceMice MammalsModalityModern ManMurineMusNecrosisNecroticNeoplasm MetastasisNerveNoduleOperative ProceduresOperative Surgical ProceduresOutcomePDX modelPancreasPancreas CancerPancreas NeoplasmsPancreas TumorPancreaticPancreatic CancerPancreatic TumorPancreatic ductPancreatitisPathological ConstrictionPatient derived xenograftPatientsPhysiologicPhysiologic pulsePhysiologicalPhysiologyPigsPlasma MembranePlayPre-Clinical ModelPreclinical ModelsPrognosisProgrammed Cell DeathProtocolProtocols documentationPulseRecurrenceRecurrentRiskRoleSafetySecondary NeoplasmSecondary TumorSeriesSiteSolid NeoplasmSolid TumorSpectroscopySpectrum AnalysesSpectrum AnalysisStenosisStructural defectStructural malformationStructureSuidaeSurgicalSurgical InterventionsSurgical ProcedureSurvival RateSwineTechniquesTechnologyTestingTheoretical StudiesTherapeuticTimeTissuesTreatment ProtocolsTreatment RegimenTreatment ScheduleTumor BurdenTumor ImmunityTumor LoadTumor TissueUnited StatesUnresectableWidthWirsung canalWorkanti-tumor immune responseanti-tumor immunityantitumor immunitybiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencescancer cellcancer immunitycancer metastasiscancer microenvironmentcancer progressionchemo/radiation therapychemotherapy and radiotherapyclinical relevanceclinical translationclinically relevantclinically translatabledevelopmentaleffective therapyeffective treatmentelectric fieldelectric impedanceelectroporative deliveryfightinggene electrotransferheterogeneity in tumorshost responseimmune competentimmune system responseimmunoresponseimmunosuppressed patientin vivoinjuriesintra-tumoral heterogeneityintratumor heterogeneityinventionionizationmalignancymodel of animalmouse modelmurine modelnano meter scalenano meter sizednanometer scalenanometer sizednanoscalenecrocytosisneoplasm progressionneoplasm/cancerneoplastic progressionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpancreatic cancer cellspancreatic cancer modelpancreatic cancer patientspancreatic malignancypancreatic neoplasiapancreatic neoplasmpancreatic tumor cellspancreatic tumor modelpatient derived xenograft modelpatients with pancreatic cancerphysical propertypig modelpiglet modelplasmalemmaporcineporcine modelpost treatmentpre-clinicalpre-clinical studypreclinicalpreclinical studypreventpreventingradiation or chemotherapyresponsesocial rolestructural abnormalitiesstructural anomaliessuidsurgeryswine modeltranslation to humanstreatment strategytumortumor ablationtumor cell metastasistumor heterogeneitytumor microenvironmenttumor progressiontumor xenograftvascular
Description preview
PROJECT SUMMARY: Pancreatic cancer accounts for approximately 3% of all cancers in the United States
and approximately 7% of all cancer related deaths. New treatment paradigms are direly needed. Emerging
tumor ablation techniques have shown significant promise. This proposal will focus on High-Frequency
Irreversible Electroporation (H-FIRE), which…
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