grant
Optimization of a Treatment for Sjögren's Disease Using Aspirin-Triggered Resolvin D1 and Dexamethasone
Organization UNIVERSITY OF MISSOURI-COLUMBIALocation COLUMBIA, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025ALXRAcetylsalicylic AcidAdrenal Cortex HormonesAnti-SmithAntinuclear AntibodiesAntinuclear FactorsAsialiaAspirinAutoimmuneAutoimmune DiseasesBiodistributionBlood PlasmaBuccal CavityBuccal Cavity Head and NeckCavitas OrisCell BodyCellsCellular Immune FunctionChronicClinicalClinical TreatmentClinical TrialsCorticoidsCorticosteroidsCoupledCytokine Signal TransductionCytokine SignalingDevelopmentDexamethasoneDiagnosticDiseaseDisease ProgressionDisorderDoseDrugsEffectivenessEpithelial CellsEpitheliumExhibitsFPR2FPR2 geneFPRH1FPRL1FemaleFollow-Up StudiesFollowup StudiesFormyl Peptide Receptor 2Formyl Peptide Receptor Homolog 1Formyl Peptide Receptor-Like 1G-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHM63HumanHyposalivationInflammationInflammatoryInflammatory InfiltrateInvestigationLXA4RLipoxin A4 ReceptorLymphatic cellLymphocyteLymphocyticLymphocytic InfiltrateMacrophageMath ModelsMediatingMediatorMedicationMiceMice MammalsModern ManMouthMouth DrynessMurineMusMφOnset of illnessOral cavityOral healthPathway interactionsPatientsPharmaceutical PreparationsPlasmaPlasma SerumProduce salivaQOLQuality of lifeReceptor ProteinResolutionReticuloendothelial System, Serum, PlasmaSalivaSaliva productionSalivary Gland TissueSalivary GlandsSalivary excretionSalivary hypofunctionSalivationSialadenitisSialoadenitisSicca SyndromeSignal PathwaySjogren's DiseaseSjogren's SyndromeSjogrensSjögren SyndromeSteroid CompoundSteroidsSubmandibular glandSubmaxillary GlandSystemTimeTranslatingTreatment outcomeWomanXerostomiaXerostomicadaptive immunityanti-DNA autoantibodyanti-SmantiDNA autoantibodyantinuclear autoantibodyaptyalismassociated symptomautoimmune conditionautoimmune disorderautoimmunity diseaseclinical interventionclinical therapyclinical translationclinically translatableco-morbid symptomco-occuring symptomcomorbid symptomconcurrent symptomcooccuring symptomcostcost effectivecytokinedental healthdevelopmentaldisease onsetdisorder onsetdosagedrug/agentdry moutheffective therapyeffective treatmenthuman diseasehumanized micehumanized mouseimmune functionimprovedin vivoloss of functionlymph cellmathematic modelmathematical modelmathematical modelingmouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoral drynesspathwaypreservationpreventpreventingreceptorresolutionsresponsesaliva secretionsalivary gland hypofunctionsalivary gland inflammationsalivary productionsalivary secretionside effectsymptom associationsymptom comorbiditytherapy optimizationtissue repairtreatment optimizationtrial regimentrial treatmentxerodermosteosis♀
Description preview
ABSTRACT
Sjögren's disease is an autoimmune condition characterized by chronic inflammation and diminished secretory
function of the salivary glands. Although extensive investigation has been done to understand it, causes of and
effective treatments for the disease are still unknown. Given the high degree of need and the limitations of current…
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