grant
Optimization and development of extracellular matrix-targeting probes for PET-based assessment of lung fibrosis disease activity
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AddressAdvisory CommitteesAffinityAirway failureAnimal ModelAnimal Models and Related StudiesApplied SkillsAwardBacterial AdhesinsBindingBiologyBleoBleomycinCell Communication and SignalingCell SignalingCell-Extracellular MatrixCessation of lifeCharacteristicsChemicalsChemistryCicatrixClinicalClinical ResearchClinical StudyCold-Insoluble GlobulinsCollagenDeathDecision MakingDedicationsDepositDepositionDetectionDevelopmentDiagnosisDiseaseDisease ManagementDisease ProgressionDisorderDisorder ManagementDoseDropsyDrug KineticsECMEdemaEffectivenessElementsExtracellular MatrixExtracellular Matrix ProteinsFDA approvedFN1Fibrillar CollagenFibronectin 1FibronectinsFibrosing AlveolitisFibrosisFibrotic lesions in lungFoundationsFutureGlycoproteinsGoalsHalf-LifeHigh Resolution Computed TomographyHumanHydropsIND FilingIND applicationIND packageIND submissionImageIn VitroInflammatoryInjectionsInjuryInterventionIntracellular Communication and SignalingInvestigational New Drug ApplicationLETS ProteinsLarge External Transformation-Sensitive ProteinLungLung Function TestsLung Respiratory SystemLung Tissue FibrosisLung damageLung scarLung tissue scarMacrogolsMedicineMentorshipMethodsMiceMice MammalsModalityModelingModern ManMolecular InteractionMolecular ProbesMonitorMorbidityMorbidity - disease rateMurineMusNew Drug ApprovalsNoiseOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOrganOutcomePETPET ScanPET imagingPETSCANPETTPathologicPatient CarePatient Care DeliveryPatientsPeptidesPerformancePersonsPharmacokineticsPharmacologyPhasePolyethylene GlycolsPolyethylene OxidePolyethyleneoxidePolyoxyethylenesPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyProcessPublic HealthPulmonary FibrosisPulmonary ScarPulmonary Tissue fibrosisPulmonary function testsRad.-PETRadiation exposureRadiolabeledResearchResearch InfrastructureResearch ResourcesResourcesRespiratory FailureRoleS. pyogenesScarring at the lungScarring in the lungScarsSignal TransductionSignal Transduction SystemsSignalingSourceStreptococcus Group AStreptococcus pyogenesTask ForcesTestingTherapeuticTimeTrainingTumor CellUniversitiesWisconsinWorkWound Repairadhesinadvisory teamalpha 2-Surface Binding Glycoproteinanaloganimal imagingantifibrotic agentantifibrotic medicationantifibrotic therapyantifibrotic treatmentbiological signal transductioncare for patientscare of patientscareercaring for patientsclinical applicabilityclinical applicationclinical translationclinically translatabledevelopmentaldiffuse interstitial pulmonary fibrosisfibrosis in the lungfibrotic lunggroup A strephigh resolution CThuman diseaseidiopathic pulmonary fibrosisimage-based methodimagingimaging biomarkerimaging markerimaging methodimaging modalityimaging probeimaging-based biological markerimaging-based biomarkerimaging-based markerimmunogenicityimprovedin vivoinjuriesinnovateinnovationinnovativelongitudinal imaginglung fibrosislung injurymodel of animalmolecular imagingmolecule imagingmortalitynano-molarnanomolarneoplastic cellnon-invasive monitornoninvasive monitornoveloptimal therapiesoptimal treatmentspositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpre-clinical developmentpreclinicalpreclinical developmentpreservationpulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryradiolabelradiolabelingradiolabelsradiologically labeledradiotracerresponseresponse to therapyresponse to treatmentscaffoldscaffoldingserial imagingsocial roletherapeutic responsetherapy responsetooltraining opportunitytreatment responsetreatment responsivenessuptakewound healingwound recoverywound resolution
Description preview
Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing disease characterized by relentless extracellular
matrix (ECM) deposition and lung stiffening that leads to death 3-4 years after diagnosis. IPF disease monitoring
largely relies on high-resolution computed tomography imaging and pulmonary function tests, which are unable
to assess ECM…
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