grant
Optical Assessment of Photoreceptor Function and Integrity
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 1 Sept 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025AgeAlgorithmic SoftwareAlgorithmic ToolsAlgorithmsAreaArtifactsAssessment instrumentAssessment toolBiological MarkersBlindnessBlood flowCategoriesCell BodyCell Communication and SignalingCell DeathCell SignalingCellsCellular injuryCessation of lifeCharacteristicsChoroideremiaClinicClinicalClinical ResearchClinical StudyColor VisionsComplexComputer softwareConeCone PhotoreceptorsCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyData BasesDatabasesDeathDiabetic RetinopathyDiagnosisDiminished VisionDiseaseDisease Frequency SurveysDisease ProgressionDisorderDoppler OCTEarly DiagnosisEarly treatmentElectrodesElectroretinographyEyeEye diseasesEyeballFamilyFeedbackFunctional ImagingGeneral HospitalsGenotypeGoalsHereditaryImageImaging technologyImpairmentInheritedInterventionIntracellular Communication and SignalingInvestigatorsLabelLaser ElectromagneticLaser RadiationLasersLeadLightLongitudinal StudiesLow VisionMassachusettsMeasurementMeasuresMediatingMedicalMonitorMorphologic artifactsMorphologyMotionMovementNerve Impulse TransmissionNerve TransmissionNeuronal TransmissionNoiseOCT TomographyOCT angiographyOCTAOptical Coherence TomographyOpticsOutcomePartial SightPathologyPatientsPatternPb elementPerformancePerimetryPhasePhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiologicPhysiologic ImagingPhysiologic pulsePhysiologicalPigmentary RetinopathyProgressive Choroidal AtrophyPulseQOLQuality of lifeReduced VisionResearch PersonnelResearchersResidualResidual stateResolutionRetinaRetinal Blood VesselsRetinal ConeRetinal DegenerationRetinal DiseasesRetinal DisorderRetinal VesselsRetinitis PigmentosaSafetySamplingScanningSensorySeveritiesSeverity of illnessSightSignal TransductionSignal Transduction SystemsSignalingSoftwareSoftware AlgorithmSoftware FrameworkSourceSpeedStandardizationStimulusStretchingSubnormal VisionSurrogate MarkersSurvey InstrumentSurveysTapetoretinal DegenerationTechniquesTechnologyTestingTherapeuticTherapeutic TrialsTimeUniversitiesVariantVariationVisionVisualVisual AcuityVisual FieldsVisual ReceptorVisual impairmentagesaxon signalingaxon-glial signalingaxonal signalingbio-markersbiologic markerbiological signal transductionbiomarkerbody movementcell damagecell injurycellular damageclinical diagnosisclinical imagingclinical translationclinically translatablecohortcone celldamage to cellsdata basedegenerative retina diseasesdesigndesigningdisease severitydrug developmentearly detectionearly therapyelectroretinogrameye disordereye fieldeye imagingglia signalingglial signalingheavy metal Pbheavy metal leadimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedinherited retinal degenerationinjury to cellsinnovateinnovationinnovativeinstrumentinterdisciplinary collaborationlife spanlifespanlong-term studylongitudinal outcome studiesmaculamacularmetermultidisciplinarynanometernecrocytosisnerve signalingneural signalingneuronal signalingneurotransmissionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyocular diseaseocular disorderocular imagingophthalmic imagingophthalmopathyopticaloptical Doppler tomographyoptical coherence Doppler tomographyoptical coherence tomography angiographyparallel computationparallel computerparallel computingphysiological imagingpreservationprogramsresolutionsresponseretina blood vessel structureretina degenerationretina diseaseretina disorderretinal degenerativeretinal degenerative diseasesretinal vascular networkretinal vascular structureretinal vasculatureretinopathyrod and cone dystrophyrod-cone dystrophyspatial and temporalspatial temporalspatiotemporalsurrogate bio-markerssurrogate biomarkerstherapeutic targettooltransdisciplinary collaborationtrial designvision impairmentvision lossvisual functionvisual lossvisually impaired
Description preview
Photoreceptors are specialized sensory cells that convert light stimuli to neuronal signal. Diminished responses
to light suggest cell damage and death, which lead to poor vision and blindness. Preserving and restoring
photoreceptors are meaningful therapeutic targets for retinal degeneration. Diagnosing, managing, and drug
development require…
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