grant
Oncogenic triggers and their influence on 3D chromosomal architecture
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 12 Jun 2019Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20263-D3-D structure3-Dimensional3-dimensional structure3D3D structureAcute B-Lymphocytic LeukemiaAcute T Cell LeukemiaAcute T-Cell Lymphoblastic LeukemiaAcute T-Cell Lymphocytic LeukemiaAcute T-Lymphocytic LeukemiaAcute leukemiaArchitectureAreaB cell progenitor acute lymphoblastic leukemiaB lymphomaB-ALLB-Cell Acute Lymphocytic LeukemiaB-Cell Acute Lymphoblastic LeukemiaB-Cell LeukemiaB-Cell Lymphoblastic LeukemiaB-Cell LymphomasB-cell ALLB-cell precursor acute lymphoblastic leukemiaBasal Transcription FactorBasal transcription factor genesBindingBiologicalBody TissuesCD34CD34 geneCRISPR approachCRISPR based approachCRISPR interferenceCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR-dCas9-mediated repressionCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCancersCas nuclease technologyCell BodyCellsCellular TransformationChildhoodChildhood LeukemiaChromatinChromatin LoopChromatin Loop DomainsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats interferenceClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsComplexComputational toolkitCopy Number PolymorphismDLBCLDNADNA LoopDNA mutationDeoxyribonucleic AcidDiffuse Large B-Cell LymphomaDiseaseDisorderDrug TherapyElementsEngineering / ArchitectureEnhancersEventGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic ChangeGenetic defectGenetic mutationGerminoblastic SarcomaGerminoblastomaHPCA1Hematopoietic Cell TumorHematopoietic MalignanciesHematopoietic NeoplasmsHematopoietic Neoplasms including LymphomasHematopoietic TumorHematopoietic and Lymphoid Cell NeoplasmHematopoietic and Lymphoid NeoplasmsHeterogeneityHumanIn VitroIndividualLinkLymphocytic NeoplasmLymphocytic TumorLymphocytic and Plasma Cell NeoplasmLymphocytic and Plasma Cell TumourLymphocytic and Plasmacytic NeoplasmLymphoidLymphoid TumorLymphoid and Plasma Cell TumourLymphoid and Plasmacytic NeoplasmLymphoid and Plasmacytic TumourLymphomaMaintenanceMalignantMalignant - descriptorMalignant Hematopoietic NeoplasmMalignant LymphomaMalignant NeoplasmsMalignant TumorMapsMature LymphocyteMediatingMethodsModern ManMolecularMolecular InteractionMutationNeoplasmsNon-Polyadenylated RNANuclearOncogenicPatientsPediatric LeukemiaPharmacological TreatmentPharmacotherapyPhenotypePre-B-Cell LeukemiaPrecursor B Lymphoblastic LeukemiaPrecursor T Lymphoblastic LeukemiaProgenitor CellsProteinsRNARNA Gene ProductsRegulatory ElementReticulolymphosarcomaRibonucleic AcidSamplingSeminalShapesSomatic MutationSystemT-Cell LeukemiaT-Cell Lymphocytic LeukemiaT-Cell Type Acute LeukemiaT-CellsT-LymphocyteT-Lymphocytic LeukemiaT-lineage acute lymphoblastic leukemiaTestingTissuesTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional Regulationbiologicblood cancerblood neoplasmcancer cell genomecancer genomecancer of bloodcancer of the bloodcancer progressioncell typechildren with leukemiacohesincomputational toolboxcomputational toolscomputational toolsetcomputerized toolscopy number variantcopy number variationdisease riskdisorder riskdrug interventiondrug treatmentexperimentexperimental researchexperimental studyexperimentsgene networkgenome mutationin silicoin vivolarge cell Diffuse non-Hodgkin's lymphomaleukemialeukemia in childrenleukemia/lymphomalymphoid neoplasmlymphoma/leukemiamalignancymetaplastic cell transformationmultiomicsmultiple omicsneoplasianeoplasm progressionneoplasm/cancerneoplastic growthneoplastic progressionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpanomicspediatricpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprogramspromoterpromotorrepressing CRISPR-dCas9 systemresponseresponse to therapyresponse to treatmentscATAC sequencingscATAC-seqscreeningscreeningssingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell sequencing assay for transposase accessible chromatinsingle moleculesingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsomatic variantstem cellsstructural mutationstructural variantstructural variationtherapeutic responsetherapy responsethree dimensionalthree dimensional structurethymocytethymus derived lymphocytetooltranscription factortreatment responsetreatment responsivenesstreatment risktumor genometumor progression
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PROJECT 3: PROJECT SUMMARY
Recent studies connected 3D nuclear and chromosomal architecture to the regulation of gene expression in
multiple tissues and cell types. PIs in this Program Project were some of the first to link 3D topology to cellular
transformation in human leukemia. We identified mutations that can impact DNA looping (targeting CTCF…
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