grant
Oncogenic Kinases in Cancer
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AntibodiesAntibody-drug conjugatesBreast CancerCancer PatientCancersCell SurvivalCell ViabilityColorectal CancerDevelopmentEpidermoid CarcinomaEsophageal CancerEsophagus CancerGoalsHNSCCHead and Neck CancerHead and Neck CarcinomaHead and Neck Squamous Cell CarcinomaKinasesMalignant Breast NeoplasmMalignant CellMalignant Esophageal NeoplasmMalignant Esophageal TumorMalignant Head and Neck NeoplasmMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the EsophagusMalignant Tumor of the OvaryMalignant neoplasm of esophagusMalignant neoplasm of ovaryModalityMolecularOncogenesisOncogenicOvary CancerPhosphotransferase GenePhosphotransferasesPlanocellular CarcinomaPlayRoleSCCHNSquamous CarcinomaSquamous Cell EpitheliomaSquamous cell carcinomaTherapeutic InterventionTransphosphorylasescancer celldevelopmentalhead and neck squamous carcinomahead and neck squamous cell cancerhead/neck cancerinhibitorintervention therapylung tumorigenesismalignancymalignant breast tumormalignant head and neck tumorneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoesophageal cancerovarian cancerpersonalized drugsprecision drugssocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttumorigenesistumorigenesis in the lung
Description preview
We are focused on novel drivers of the 3q amplicon that play a critical role in promoting tumorigenesis in lung squamous cell carcinoma, head and neck cancer, and ovarian cancer. These novel drivers can serve as targets of therapeutic intervention and we are focused on the mechanisms by which these amplified kinases promote tumorigenesis. We are…
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