grant
Oncogenic Impact of eIF4E-dependent RNA Export in Cancer
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Apr 1999Deadline 28 Feb 2028
NIHUS FederalResearch GrantFY20251-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide5' Capped RNA5' mRNA Cap StructureAML - Acute Myeloid LeukemiaAML M5ActinsAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAcute monocytic leukemiaAdherenceAnti-viral AgentsBindingBinding SitesBiochemicalBiologicalBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCD44CD44 Adhesion ReceptorCD44 AntigensCD44 geneCD44 moleculeCancer PatientCancersCell BodyCell Communication and SignalingCell LineCell LocomotionCell MigrationCell MovementCell SignalingCell membraneCellLineCellsCellular MatrixCellular MigrationCellular MotilityClinicCombining SiteComplexCytoplasmic MembraneCytoskeletal SystemCytoskeletonDNADeoxyribonucleic AcidDevelopmentDiseaseDisease remissionDisorderEarly-Stage Clinical TrialsEncapsulatedEngraftmentEukaryotic Initiation FactorsEukaryotic Peptide Initiation FactorsEukaryotic Translation Initiation FactorsEventExtramedullaryGeneticGlycosaminoglycansHUTCH-1Head and Neck CancerHead and Neck CarcinomaHermes AntigenHyaluronanHyaluronan ReceptorsHyaluronan-Binding ProteinHyaluronic Acid Binding ProteinImpairmentIn VitroIntracellular Communication and SignalingInvadedKnowledgeLinkLiverLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMDU3Malignant CellMalignant Head and Neck NeoplasmMalignant NeoplasmsMalignant TumorMechanicsMembraneMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMolecularMolecular InteractionMorphologyMotilityMucopolysaccharidesMyeloid Leukemia, Acute, M5Neoplasm MetastasisNewly DiagnosedNon-Polyadenylated RNANormal CellNuclear ExportNuclear RNAOncogenicOutcomePatientsPgp1Phase 1 Clinical TrialsPhase I Clinical TrialsPhosphorylationPhysiologicPhysiologicalPlasma MembraneProcessProductionProliferatingPropertyProstateProstate GlandProstatic GlandProtein PhosphorylationProteinsRNARNA CapsRNA Gene ProductsRNA ProcessingReactive SiteReceptor ProteinRegulonRemissionResearch SpecimenRibavirinRibonucleic AcidRibovirinRoleSchilling-Type Myeloid LeukemiaSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSiteSolidSpecimenSpleenSpleen Reticuloendothelial SystemStrains Cell LinesSurvey InstrumentSurveysTherapeutically TargetableTissuesTranscriptTranslationsTribavirinTumor Cellacute granulocytic leukemiaacute granulocytic leukemia cellacute monoblastic leukemiaacute myeloblastic leukemia cellacute myelocytic leukemia cellacute myelogenous leukemia cellacute myeloid leukemiaacute myeloid leukemia cellacute nonlymphocytic leukemia cellanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsbiologicbiological signal transductioncancer cellcancer metastasiscartilage link proteincell motilitycultured cell linedevelopmentalezringp85head/neck cancerhepatic body systemhepatic organ systemhome based monitoringhome monitoringin vivointracellular skeletonleukemialink proteinlymph glandlymph nodeslymphnodesmalignancymalignant head and neck tumormechanicmechanicalmembrane structuremigrationmouse modelmurine modelneoplasm/cancerneoplastic cellnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachoverexpressoverexpressionpharmacologicphase I protocolphosphoprotein p81plasmalemmaprogramsprotein functionreceptorresponsesocial roletranslationtumortumor cell metastasis
Description preview
Abstract
This renewal application investigates the impact of dysregulated RNA processing in cancer.
Dysregulation of these events can elevate the production of proteins that function in all facets of
malignancy, without altering their transcript levels. The eukaryotic translation initiation factor
eIF4E, dysregulated in many cancers including in…
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