grant
Onco-immunologic factors contributing to OPSCC among people living with HIV
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 20 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAIDS VirusAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActivities of Daily LivingActivities of everyday lifeAntigensAntioncogene Protein p53Antitumor ResponseBloodBlood Reticuloendothelial SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCancer GenesCancer-Promoting GeneCancersCell BodyCell CycleCell Cycle ProgressionCell Division CycleCellsCellular Tumor Antigen P53ChronicClinicalCoupledDNA ReplicationDNA SynthesisDNA biosynthesisDataDevelopmentDistantDysfunctionEarly identificationEpithelial CellsEpitheliumEquilibriumExposure toFunctional disorderFunctional impairmentGenderGene ExpressionGene TranscriptionGeneral PopulationGeneral PublicGenetic TranscriptionGenotypeGoalsHIVHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV InfectionsHIV env Protein gp120HIV tat ProteinHPVHPV + oropharyngeal carcinomaHPV 16HPV 18HPV caused cancerHPV driven cancersHPV induced cancerHPV infectionHPV malignancyHPV mediated oropharynx cancerHPV oropharyngeal cancerHPV positiveHPV positive oropharyngeal cancerHPV positive oropharynx cancerHPV related oropharyngeal cancerHPV related oropharyngeal carcinomaHPV(+)HPV+HPV+ OPCHPV+ cancerHPV+ oropharyngeal cancerHPV-16HPV-18HPV-High RiskHPV-OPCHPV-Related MalignancyHPV-associated cancerHPV-associated malignancyHPV-associated oropharyngeal cancerHPV-driven oropharyngeal cancerHPV-related OPCHPV-related cancerHPV-related oropharyngeal cancerHPV16HPV18HTLV-III InfectionsHTLV-III gp120HTLV-III-LAV InfectionsHead and Neck CancerHead and Neck CarcinomaHigh Risk Oncogenic HPVHigh risk HPVHigh risk Human PapillomavirusHigh risk Human papilloma virusHuman Immunodeficiency VirusesHuman Papilloma VirusHuman Papilloma Virus-Related MalignancyHuman Papilloma Virus-Related Malignant NeoplasmHuman Papilloma Virus-associated cancerHuman Papilloma Virus-associated malignancyHuman Papilloma Virus-related cancerHuman PapillomavirusHuman T-Lymphotropic Virus Type III InfectionsHuman papilloma virus infectionHuman papilloma virus type 16Human papilloma virus type 18Human papillomavirus 16Human papillomavirus 18Human papillomavirus cancerHuman papillomavirus driven oropharyngeal cancerHuman papillomavirus induced cancerHuman papillomavirus infectionHuman papillomavirus malignancyHuman papillomavirus related oropharyngeal carcinomaHuman papillomavirus type 16Human papillomavirus type 18Human papillomavirus- related oropharyngeal cancerHuman papillomavirus-Related MalignancyHuman papillomavirus-Related Malignant NeoplasmHuman papillomavirus-associated oropharyngeal cancerImmuneImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune EvasionImmune SurveillanceImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunityImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologic DiseasesImmunologic FactorsImmunologic SurveillanceImmunological DiseasesImmunological DysfunctionImmunological FactorsImmunological System DysfunctionImmunosuppressed HostImmunosurveillanceImpairmentIndividualInfectionInfectious Human Wart VirusInfiltrationInflammationInterventionLAV-HTLV-IIILYT3Life CycleLife Cycle StagesLiteratureLong-term infectionLymphadenopathy-Associated VirusMalignantMalignant - descriptorMalignant Head and Neck NeoplasmMalignant NeoplasmsMalignant Oropharyngeal NeoplasmMalignant Oropharyngeal TumorMalignant TumorMediatingModelingOncogene ProductsOncogene ProteinsOncogenesOncogenesisOncogenicOncoprotein p53OncoproteinsOropharnyx CancersOropharyngealOropharyngeal CancerOropharyngeal CarcinomaOropharynxOropharynx CancerOropharynx CarcinomaOropharynxsOutcomeP105-RBP53PBMCPP110PathogenesisPathway interactionsPeripheral Blood Mononuclear CellPersonsPhosphoprotein P53Phosphoprotein pp53PhysiopathologyPrecancerous CellsPredispositionPremalignant CellPrevalencePreventionProbabilityProcessProductionPrognosisProliferatingProtein TP53ProteinsPublishingRNA ExpressionRb Gene ProductRb ProteinRb1 Gene ProductResearch DesignResearch SpecimenRetinoblastoma Associated ProteinRetinoblastoma ProteinRetrospective StudiesSpecimenStaining methodStainsStudy TypeSusceptibilityT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTP53TP53 geneTRP53TestingTranscriptionTransforming GenesTumor CellTumor EscapeTumor Immune EscapeTumor ImmunityTumor Protein p53Tumor Protein p53 GeneViralVirusVirus-HIVWorkanti-tumor immunityanti-tumor responseantiretroviral therapyantiretroviral treatmentantitumor immunitybalancebalance functioncancer evasioncancer immune escapecancer immune evasioncancer immunitycancer initiationcancer microenvironmentcell transformationchronic infectionco-infectioncoinfectiondaily living functiondaily living functionalitydevelopmentalexhaustexhaustionfunctional abilityfunctional capacitygp120gp120 ENV Glycoproteingp120(HIV)head/neck cancerhigh riskhrHPVhuman papilloma virus 16human papilloma virus 18human papillomavirus +human papillomavirus associated malignancyhuman papillomavirus caused cancerhuman papillomavirus driven cancershuman papillomavirus mediated oropharynx cancerhuman papillomavirus positivehuman papillomavirus positive oropharyngeal cancerhuman papillomavirus positive oropharyngeal carcinomahuman papillomavirus positive oropharynx carcinomahuman papillomavirus+ oropharyngeal cancerhuman papillomavirus-associated cancerhuman papillomavirus-related cancerimmune activationimmune evasiveimmunogenimmunologic substanceimmunological substanceimmunosuppressed patientimprovedinsightlife coursemalignancymalignant head and neck tumormalignant oropharynx neoplasmmalignant oropharynx tumorneoplasm/cancerneoplastic celloral pharyngealp53 Antigenp53 Genesp53 Tumor SuppressorpRBpathophysiologypathwaypersistent infectionprecancerprecancerouspremalignantpresence of HPVpresence of human papillomavirusprospectiveprotein p53racial diversityracially diversereconstitutereconstitutionrestorationstudy designthree dimensionalthymus derived lymphocytetransformed cellstumortumor evasiontumor immune evasiontumor microenvironmenttumorigenesistype 16 Human papilloma virustype 16 Human papillomavirusviral DNAviral microbiomeviromevirus DNAwart virus
Description preview
Oropharyngeal cancer (OPC) is a type of head and neck cancer and ~70% cases of OPC are associated with
high-risk (hr) human papillomaviruses (HPV) infection. OPC cancers are increasing in prevalence especially in
persons living with HIV (PWH) and this group also has higher rates on HPV associated OPC. Reasons for these
findings are not well…
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