grant
Oklahoma C. difficile U19 Challenge Core
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 25 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025Animal ModelAnimal Models and Related StudiesAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsC diffC difficileC. diffC. diff vaccineC. difficileC. difficile vaccineClostridioides difficileClostridioides difficile vaccineClostridium difficileClostridium difficile vaccineCricetinaeDataDedicationsDiseaseDisorderDoseEnsureEnvironmentGI microbiomeGenerationsGoalsHamstersHamsters MammalsHealthIndividualInfectionInvestigatorsJointsLaboratoriesMeasuresMethodsMiceMice MammalsMiscellaneous AntibioticModalityModelingMonitorMurineMusOklahomaOralOutcomePredispositionProceduresPublic HealthPublicationsR-Series Research ProjectsR01 MechanismR01 ProgramReagentRecurrenceRecurrentRecurrent diseaseRelapsed DiseaseReproducibilityReproduction sporesResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersScientific PublicationServicesSporesStandardizationSusceptibilityVaccinatedVaccinationVariantVariationWithdrawalbacterial disease treatmentbacterial infectious disease treatmentdigestive tract microbiomeefficacy testingenteric microbiomeevaluate vaccinesexperienceexperimentexperimental researchexperimental studyexperimentsgastrointestinal microbiomegut microbiomegut-associated microbiomeinfection recurrenceinterestintestinal biomeintestinal microbiomemicrobiomemodel of animalmouse modelmurine modelpathogenprogramsrecurrent infectionrecurring infectionvaccine candidatevaccine efficacyvaccine evaluationvaccine responsevaccine responsivenessvaccine screeningvaccine testingvaccine-induced responsevaccines against C . Difficilevaccines against Clostridioides difficile
Description preview
Project Summary (Challenge Core)
The central goal of the Oklahoma C. difficile U19 program is to advance a second-generation vaccine for C.
difficile by revealing mechanisms that limit protective vaccine-induced responses. In order to achieve these
goals, challenge experiments are required whereby relevant animal models are used to test vaccine…
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