grant
Nutritional landscape and community interactions in the vaginal microbiome
Organization UNIVERSITY OF TENNESSEE KNOXVILLELocation KNOXVILLE, UNITED STATESPosted 8 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AutoregulationBioavailabilityBiological AvailabilityBionomicsClassificationCommunitiesComplexCristobaliteDataEcologic SystemsEcological SystemsEcologyEcosystemEnvironmentGeneticGoalsHealthHomeostasisImmune responseIndividualIntermediary MetabolismIonsKnowledgeLactobacillusLinkMetabolicMetabolic ProcessesMetabolismMetalsMicrobeModelingMucinsMucus GlycoproteinNatureNutrientNutrient availabilityNutritionalOrganismPhysiologicPhysiologic AvailabilityPhysiologicalPhysiological HomeostasisReproductive HealthRoleSandShapesSilicaSilicon DioxideStructureSystematicsTridymiteVaginaWorkbacterial communitycervicovaginalcommunity microbesdysbacteriosisdysbiosisdysbiotichost responseimmune system responseimmunoresponsein vivointerdisciplinary approachliving systemmembermicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobial imbalancemicrobial interactionmicrobiotamicrofloramicroorganism communitymicroorganism interactionmultidisciplinary approachmultispecies consortianutritiouspolymicrobial communitysocial rolesynergismtherapeutic targetvaginal biomevaginal floravaginal microbial communityvaginal microbiomevaginal microbiotavaginal microfloravaginal mucosa
Description preview
PROJECT SUMMARY
The vaginal tract is a harsh, polymicrobial ecosystem that has an active immune response, is rich in
cervicovaginal mucins, and has a robust microbiota. Bacterial persistence within this environment requires the
ability of organisms to adapt to changes in nutrient availability and to interact with the other members of the…
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