grant
Nuclear moonlighting of arsenic metabolic enzymes and reprogramming-resistant epimutations
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 23 Jan 2025Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2026ArsenicAutomobile DrivingBS-seqBindingBisulfite-based sequencingCarbonCell BodyCell NucleusCell ReprogrammingCellsChIP SequencingChIP-seqChIPseqChemicalsChromatinCoupledCuesDNADNA MethylationDataData SetDeoxyribonucleic AcidDevelopmentES cellEcological impactEnvironmental ExposureEnvironmental ImpactEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFunctional RNAGametesGene TranscriptionGenerationsGenetic TranscriptionGenomicsGerm CellsGerm-Line CellsGoalsHeritabilityHomocysteineHypermethylationIn VitroIntermediary MetabolismLaboratoriesMaintenanceMediatingMemoryMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismMethionineMethylationModelingModificationMolecularMolecular InteractionMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsNoncoding RNANontranslated RNANuclearNucleusOutcomePathway interactionsPhysiologicPhysiologicalPrimordial Germ CellRNA ExpressionRNA SeqRNA sequencingRNAseqReproductive CellsResearchResistanceRoleSex CellStructure of primordial sex cellTestingTranscriptionTransplantationUntranslated RNAWorkarsenicsbisulfite sequencingbisulfite-seqcellular reprogrammingchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclass developmentcourse developmentcourse material developmentdevelopmentaldrivingembryo derived stem cellembryonal stem cellsembryonic progenitorembryonic stem cellentire genomeenvironmental chemicalepigenetic memoryepigeneticallyepigenomeexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfull genomehistone methylationhistone modificationin vivoinitial celllarge data setslarge datasetsmESCmetabolism measurementmetabolomicsmetabonomicsmurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellneurobehavioralnoncodingoffspringpathwayprogramsreproductiveresistantresponsesexual cellsocial rolesodium arsenitesodium metaarsenitestem cell of embryonic origintoxicanttranscriptome sequencingtranscriptomic sequencingtransgenerational epigenetic inheritancetransgenerational inheritancetransplantwhole genome
Description preview
PROJECT SUMMARY
The overarching goal of the research presented in this application is to understand how environmental
chemicals trigger a deregulation of the epigenome that can resist epigenetic reprogramming in germ cells and
therefore can become heritable.
Inorganic arsenic (iAs) is a model epigenetic toxicant owing to its well described…
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