grant
Nuclear and non-nuclear functions of NKX3.1 in suppression of prostate cancer
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AccelerationAgingBasal Transcription FactorBasal transcription factor genesBindingBioenergeticsCancersCarcinomaCell AgingCell BodyCell NucleusCell SenescenceCellsCellular AgingCellular SenescenceCommunicationDNADNA mutationDataDeoxyribonucleic AcidDisease ProgressionEpithelial cancerEpithelium of Human Prostate GlandExclusionGEM modelGEMM modelGatekeepingGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetically Engineered MouseHOX geneHomeo Box GenesHomeobox Family GeneHomeobox GenesHomeobox Protein NKX-3.1Homeobox Protein NKX3AHomeodoamin GeneHomeotic GenesHumanImpairmentIn VitroInflammationInvestigationLoxP-flanked alleleMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMediatingMiceMice MammalsMitochondriaMitochondrial DNAModelingModern ManMolecular InteractionMurineMusMutant Strains MiceMutateMutationNK Homeobox Family 3 Subunit A HomologNK3 Transcription Factor Homolog ANK3 Transcription Factor Related ProteinNKX3-1 geneNKX3.1NKX3ANkx-3.1 proteinNuclearNucleusOrganoidsOxidative PhosphorylationOxidative Phosphorylation PathwayOxidative RegulationOxidative StressPathogenicityPatientsPhenotypePlayProcessProstateProstate CAProstate CancerProstate GlandProstate malignancyProstatic EpitheliumProstatic GlandPublishingRNA ExpressionReplicative SenescenceRisk FactorsRoleStudy modelsSystems BiologyTelomere ShorteningTestingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTumorigenicityValidationVariantVariationWorkadvanced prostate canceraging associatedaging relatedbase editingbiobankbiorepositorycancer progressioncohortepithelial carcinomafloxedfloxed allelegatekeepergenetically engineered mouse modelgenetically engineered murine modelgenome mutationhallmarks of agingin vivoinsightloss of functionmalignancymitochondrialmitochondrial DNA mutationmitochondrial dysfunctionmouse modelmouse mutantmtDNAmtDNA mutationmurine modelneoplasm progressionneoplasm/cancerneoplastic progressionnovelpillars of agingprostate cancer cellprostate cancer progressionprostate tumor cellreplicative agingresponsesenescencesenescentsocial rolesynergismtelomeretelomere attritiontooltranscription factortranscriptomicstumortumor progressionvalidations
Description preview
Project Summary/Abstract
Our studies will investigate mechanisms associated with aging-related prostate cancer progression
through our investigations of the prostate-specific homeobox gene NKX3.1. Work by us and others has shown
that NKX3.1 is essential for normal prostate differentiation, whereas its loss promotes prostate cancer during
aging.…
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