NSF/Bio-DFG: Structural and functional characterization of NOSIP, an unusual cargo of the nuclear import receptor transportin

All proteins are made in the cytoplasm, but thousands must enter the nucleus. The transport of these proteins from the cytoplasm to the nucleus is thus critical for proper functions of the cell. For many such proteins, nuclear localization signals (NLS) have been identified that mediate the interaction with a nuclear import receptor, which, in…