grant
Novel Zinc-Finger Protein Regulator of Senescence and Cell Engineering
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 9 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AddressBack AcheBack PainBackacheBasal Transcription FactorBasal transcription factor genesBiologyBody TissuesCRISPRCRISPR activationCRISPR activatorCRISPR based activationCRISPR gene activationCRISPR interferenceCRISPR transcription activationCRISPR transcriptional activationCRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-dCAS9 ActivatorCRISPR-dCas9-mediated repressionCRISPR-mediated transcriptional activationCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/Cas systemCRISPR/dCas9 activationCRISPR/dCas9 interferenceCRISPR/dCas9-based transcriptional activationCRISPR/dCas9-mediated transcriptional inhibitionCRISPRaCRISPRiCell BodyCell CycleCell Division CycleCell FunctionCell PhysiologyCell ProcessCell Senescence InductionCell TherapyCellsCellular FunctionCellular PhysiologyCellular ProcessChIP SequencingChIP-seqChIPseqClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats interferenceCommon Rat StrainsDNA TherapyDataDepositDepositionDevelopmentDiseaseDisorderEngineeringGene ActivationGene ChipsGene Expression ChipGene ModifiedGene TargetingGene Transfer ClinicalGeneChipGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic InterventionGenomeGrantGrowth AgentsGrowth FactorGrowth SubstancesHealthHumanHuman EngineeringImmune PrecipitationImmunoprecipitationIntervertebral Disc Degenerative DiseaseIntervertebral Disc Degenerative DisorderIntervertebral DiskIntervertebral disc structureLinkMaintenanceMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMechanicsModelingModern ManMusculoskeletalMusculoskeletal DiseasesNerve CellsNerve UnitNeural CellNeurocyteNeuronsOutcomePhenotypePlayProcessProductionProgenitor CellsProteinsProteins Growth FactorsPublicationsPuncture procedurePuncturesRNA SeqRNA TransportRNA sequencingRNAseqRatRats MammalsRattusRepressionResearchRibonucleic Acid TransportRoleSEQ-ANScientific PublicationSequence AnalysesSequence AnalysisSubcellular ProcessT-CellsT-LymphocyteTherapeuticTissue EngineeringTissuesTranscription Factor Proto-OncogeneTranscription factor genesUpregulationZinc Finger DomainZinc Finger MotifsZinc Fingersactivating CRISPR technologybioengineered tissuecell based interventioncell engineeringcell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular aging inductioncellular engineeringcellular senescence inductioncellular therapeuticcellular therapychromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingdegenerated intervertebral discdegenerative disc diseasedevelopmentaldisc degenerationengineered tissueexperimentexperimental researchexperimental studyexperimentsexpression arraygene expression microarraygene modificationgene repair therapygene therapygene-based therapygenetic therapygenetically modifiedgenomic therapyimprovedin vivointervertebral disk degenerationmechanicmechanicalmusculoskeletal disorderneuronalnovelrepressing CRISPR-dCas9 systemsenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescence inductionsenescentsenescent associated secretomesenescent associated secretory phenotypesenescent cellsocial rolestem cellssubcutaneoussubdermaltherapeutic outcometherapy outcomethymus derived lymphocytetooltranscription factortranscriptome sequencingtranscriptomic sequencingvector
Description preview
Cell engineering has provided the opportunity to tune cell function to address therapeutic needs and discover
novel biology. We recently performed a set of experimental CRISPR gene perturbation screens that indicated a
gene, ZNF865, which is only known through sequence analysis and does not have any in depth publications to
date, has significant…
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