grant
Novel Targets for GI Hormones and Neuropeptides in Regulation of Intestinal Motility
Organization UNIVERSITY OF NEVADA RENOLocation RENO, UNITED STATESPosted 15 Sept 2025Deadline 14 Sept 2029
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPAcidsAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AffectAlimentary CanalAntibodiesAxonBehaviorBicarbonatesCGRP ReceptorsCalcitonin Gene-Related PeptideCalcitonin-Gene Related Peptide ReceptorCell BodyCell Communication and SignalingCell FunctionCell IsolationCell PhysiologyCell ProcessCell SegregationCell SeparationCell Separation TechnologyCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCirculationColonComplexCoupledCyclic AMPDefectDigestive TractDiseaseDisorderDistalDuodenumElectrophysiologyElectrophysiology (science)EnteralEntericEnteric Nervous SystemExposure toFRETFluorescence Resonance Energy TransferFugu ToxinFörster Resonance Energy TransferGI TractGLP-2Gastrointestinal HormonesGastrointestinal MotilityGastrointestinal TractGastrointestinal tract structureGene ExpressionGenerationsGiant CellsHCO3HormonalHumanHydrogen CarbonatesInflammatoryInterstitial Cell of CajalIntestinalIntestinal MotilityIntestinesIntracellular Communication and SignalingKnowledgeL CellsLabelLearningLeiomyocyteMediatingMigraineMigraine HeadacheModern ManMotilityMotorMotor CellMotor NeuronsMultinucleated Giant CellsMuscleMuscle Cell ContractionMuscle CellsMuscle ContractionMuscle TissueMuscular ContractionMyocytesNatureNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeural ReceptorsNeurocyteNeuronal TransmissionNeuronsNeuropeptidesNeurophysiology / ElectrophysiologyNeuroreceptorsOrganOutcome StudyPace StimulatorsPacemakersPatternPeptide ReceptorPeptidesPolykaryocytesPopulationProliferatingRNA SeqRNA sequencingRNAseqReceptor ProteinReflexReflex actionRegulationResearchRoleSecretinSensory ReceptorsSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSiteSmall IntestinesSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellStomachStretch ReceptorsSubcellular ProcessSyncytiumTarichatoxinTechniquesTetradotoxinTetrodotoxinTherapeutic InterventionTransducersTransgenic OrganismsTzanck CellVillusadenosine 3'5' monophosphatealimentary tractaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbowelcAMPcardiac pacemaker cellcell sortingcellular targetingconfocal imagingdesigndesigningdigestive canaldysmotilitydysmotility syndromeelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsgastricgastrointestinalgene manipulationgenetic manipulationgenetically manipulategenetically perturbglia signalingglial signalingglucagon-like peptide 2hormonal regulationhormone regulationimprovedin silicoinsightinterstitial cellintervention therapymigraine therapymigraine treatmentmotility disordermotoneuronmotor behaviormotor diseasemotor disordermotor dysfunctionmuscularnerve signalingneuralneural controlneural regulationneural signalingneuromodulationneuromodulatoryneuronalneuronal signalingneuroregulationneurotransmissionnodal myocytenoveloptogeneticspacemaker cellpuffer fish toxinreceptorreceptor expressionresponsesmall bowelsocial roletimelinetranscriptome sequencingtranscriptomic sequencingtransgenic
Description preview
Summary of the Project:
Gastrointestinal (GI) motility is a complex group motor behaviors controlled by myogenic, neurogenic, hormonal
and additional levels of regulation. Previous research has demonstrated that myogenic regulation is actually
accomplished by smooth muscle cells (SMCs), interstitial cells of Cajal (ICC) and cells labeled by…
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