grant
Novel role of urinary urate in renal cystogenesis and water regulation
Organization MAYO CLINIC JACKSONVILLELocation JACKSONVILLE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase3'5'-cyclic ester of AMP5'-AMP-activated protein kinaseABC15ABCG2ABCG2 geneABCPADPKDAMP-activated kinaseAMP-activated protein kinaseAMPK enzymeAQP-CDAQP2 proteinATP-Binding Cassette, Sub-Family G (WHITE), Member 2 GeneATP-Binding Cassette, Sub-Family G, Member 2ATP-Binding Cassette, Subfamily G, Member 2Adenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdenosine, cyclic 3',5'-(hydrogen phosphate)Adult Polycystic Kidney DiseaseAffectAntidiuretic HormoneAquaporinsArginine VasopressinArgipressinAssayAutoregulationAutosomal Dominant Polycystic KidneyAutosomal Dominant Polycystic Kidney DiseaseBCRPBCRP1BenemidBioassayBiological AssayBreast Cancer Resistance ProteinCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCyclic AMPCyclic AMP-Dependent Protein KinasesCystCystic kidneyDominant Polycystic Kidney DiseaseDuctDuct (organ) structureDuctal CellDuctal Epithelial CellEST157481EquilibriumErythrocyte/Hepatoma Glucose TransporterExcretory functionExocytosisGLUTGLUT1Generalized GrowthGeneticGenetic DiseasesGlucose Transporter 1GrowthHMG CoA reductase (NADPH) kinaseHMG CoA reductase kinaseHMG coenzyme A reductase (NADPH) kinaseHomeostasisHumanHydrogen OxideHyponatremiaImmunoblottingIn VitroIntracellular Communication and SignalingInvestigationKO miceKidneyKidney CystKidney FailureKidney InsufficiencyKidney TubulesKidney Urinary SystemKinasesKnock-out MiceKnockout MiceLeadMRXMXR1MediatingMembraneMiceMice MammalsMitoxantrone Resistance ProteinModelingModern ManMurineMusNull MouseOsmolalitiesOutputPKAPathway interactionsPatientsPb elementPersonsPhosphorylationPhosphorylation SitePhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPlacenta-Specific ATP-Binding Cassette TransporterPlayPolyuriaProbenecidProtein Kinase AProtein PhosphorylationProteomeProteomicsRegulationRenal CystRenal FailureRenal InsufficiencyRenal functionRenal tubule structureRodentRodentiaRodents MammalsRoleSLC2A1SLC2A1 geneSchemeSignal TransductionSignal Transduction SystemsSignalingSiteSolute Carrier Family 2, Facilitated Glucose Transporter, Member 1Strains Cell LinesTargeted ResearchTherapeutic EffectTissue GrowthTransphosphorylasesUrateUrineV2 ReceptorsVasopressin-Neurophysin II-CopeptinVasopressinsWCH-CDWaterWater Channel ProteinsWater IntakeWater consumptionWestern BlottingWestern Immunoblottingabsorptionadenosine 3'5' monophosphateanalogantagonismantagonistaquaporin-2aquaporin-CDbalancebalance functionbeta-Hypophaminebiological signal transductioncAMPcAMP-Dependent Protein Kinasescollecting duct water channelcultured cell linedecreased level Sodiumexcretiongenetic conditiongenetic disorderglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadhydroxymethylglutaryl-CoA-reductase kinaseimprovedindexinginhibitorinnovateinnovationinnovativeintervention effectkidney functionkinase inhibitorknock-downknockdownmatrigelmembrane structurenew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyontogenyoverexpressoverexpressionpathwaypharmacologicphospho-proteomicsphosphoproteomicspre-clinicalpreclinicalpreventpreventingprotein Bprotein blottingprotein expressionprotein kinase inhibitorrenalrenal tubulescRNA sequencingscRNA-seqside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutic targettolvaptantraffickingtranscriptional reprogrammingtranscriptometranscriptomicsuptakeurate transporterurinarywater channelwater transporter
Description preview
PROJECT SUMMARY/ABSTRACT
Autosomal Dominant Polycystic Kidney Disease (ADPKD), a genetic disorder leading to progressive renal cyst
growth, affects 12 million people globally. Arginine vasopressin (AVP) is a key driver of cystogenesis, and in
rodent PKD models, the absence of AVP completely prevents cyst formation. Although V2 receptor (V2R)…
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