grant
Novel Role of Bscl2 in Cardiac Substrate Metabolism and Function
NIHUS FederalResearch GrantFY202521+ years oldAddressAdipose tissueAdultAdult HumanAdult-Onset Diabetes MellitusAgeAli-esteraseAssayAutoregulationB-esteraseBSCL2BSCL2 geneBindingBioassayBiochemicalBioenergeticsBiogenesisBiologicalBiological AssayCAP-hydrolyzing EnzymeCES1Capsaicin-Hydrolyzing EnzymeCarboxyesteraseCarboxylate EsteraseCarboxylester LipaseCarboxylesterase 1Carboxylesterase BCarboxylesterasesCarboxylic Ester HydrolaseCarboxylic Ester HydrolasesCardiacCardiac Muscle CellsCardiac MyocytesCardiocyteCardiomyopathiesCatabolismCause of DeathCell BodyCellsClinicalClosure by LigationCommon Rat StrainsCouplesCouplingDataDepositDepositionDiabetes MellitusDiabetic mouseDietDysfunctionEndoplasmic ReticulumEnergy consumptionEnergy-Generating ResourcesErgastoplasmEssential Fatty AcidsFatsFatty TissueFatty acid glycerol estersFunctional disorderGenesGeneticGrantHeLaHeartHeart Muscle CellsHeart failureHeart myocyteHela CellsHomeostasisHumanHydrolaseHydrolase Family GeneHydrolase GeneHydrolysisImageIn VitroIntermediary MetabolismIon TransportIsocarboxazid amidaseKI miceKetosis-Resistant Diabetes MellitusKnock-inKnock-in MouseKnock-outKnockoutLactamaseLigationLinkLipaseLipidsLipodystrophyLipolysisMaturity-Onset Diabetes MellitusMediatingMembraneMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaMitochondrial ProteinsModelingModern ManMolecularMolecular InteractionMorbidityMorbidity - disease rateMouse Homolog of GNG3LGMurineMusMyocardialMyocardial DiseasesMyocardial DisorderMyocardial depressionMyocardial dysfunctionMyocardiopathiesNIDDMNaproxen EsteraseNeonatalNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNon-specific CarboxylesteraseNon-specific EsteraseNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNonspecific EsteraseObesityOrigin of LifePathway interactionsPatientsPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPrevalenceProcaine EsteraseProcessProductionProteinsProteomicsRatRats MammalsRattusResearchRoleSaccharoseSiteSlow-Onset Diabetes MellitusStable Diabetes MellitusSucroseSystemT2 DMT2DT2DMTestingTherapeuticTriacylglycerolTriacylglycerol HydrolaseTriacylglycerol LipaseTriacylglycerol acylhydrolaseTributyrinaseTriglyceridaseTriglyceride LipaseTriglyceride MetabolismTriglyceridesTriolean HydrolaseType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesadiposeadiposityadult onset diabetesadulthoodagesbiologiccarboxylesterasecardiac dysfunctioncardiac failurecardiac functioncardiomyocytecorpulencediabetesdiabetes mouse modeldietsdisabilityenergy sourcefat metabolismfatty acid oxidationfunction of the heartheart dysfunctionheart functionimaginginsightketosis resistant diabetesknock-downknockdownknockinknockin micelipid metabolismmaturity onset diabetesmembrane structuremitochondrialmitochondrial dysfunctionmitochondrial metabolismmortalitymyocardium diseasemyocardium disordernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoverexpressoverexpressionpathophysiologypathwaypreventpreventingreconstitutereconstitutionseipinsocial roletranscriptome profilingtranscriptomic profilingtributyrasetype 2 DMtype II DMtype two diabeteswhite adipose tissueyellow adipose tissue
Description preview
Project Summary
Metabolic perturbations underpin a wide variety of cardiomyopathies. Currently, there are no specific treatments
for preventing the onset or progression of cardiomyopathies to heart failure, one of the leading causes of death
and disability worldwide. BSCL2/Seipin is a highly conserved endoplasmic reticulum (ER) protein widely…
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