grant
Novel regulatory networks driving human ribosome biogenesis
NIHUS FederalResearch GrantFY20250-4 weeks oldAssayAutomobile DrivingBioassayBiogenesisBiologic ModelsBiological AssayBiological ModelsBirth DefectsBody TissuesBreast Epithelial CellsCancersCell BodyCell NucleolusCellsCellular AssayCellular biologyCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationDNA Molecular BiologyDiploidDiploidyDiseaseDisorderDysfunctionEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentExplosionFailureFunctional RNAFunctional disorderGeneticGenetic DiseasesHeLaHela CellsHereditaryHousekeepingHouseworkHumanHuman Cell LineHuman GeneticsImageInheritedLeadLightLinkMCF-10AMCF10AMCF10A cellsMalignant NeoplasmsMalignant TumorMessenger RNAMicroRNAsModel SystemModern ManMolecular BiologyNewborn InfantNewbornsNon-Polyadenylated RNANoncoding RNANontranslated RNAOrganellesOrigin of LifePb elementPhotoradiationPhysiopathologyPlasmosomePost-Transcriptional Gene SilencingProcessProtein BiosynthesisProteinsRNARNA Gene ProductsRNA InterferenceRNA SilencingRNAiRegulatory PathwayReportingRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesRoleSequence-Specific Posttranscriptional Gene SilencingShort interfering RNASmall Interfering RNATechnologyTissuesUntranslated RNAWorkXenopusXenopus sp.cell assaycell biologycell typeclawed frogdesigndesigningdrivinggenetic conditiongenetic disordergenome scalegenome-widegenomewideheavy metal Pbheavy metal leadhuman diseasehuman tissueimagingmRNAmalignancymammary epithelial cellsmammary gland epithelial cellsmiRNAneoplasm/cancernew approachesnewborn childnewborn childrennoncodingnovelnovel approachesnovel strategiesnovel strategynucleolusoverexpressoverexpressionpathophysiologyprotein synthesisribosomopathyscreeningscreeningssiRNAsocial roletissue/cell culture
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Project Summary/Abstract
Over the last 20 years there has been an explosion in the number of recognized human genetic diseases of
making ribosomes, the ribosomopathies, most of which are inherited, congenital conditions. Despite the clear
impact of abnormalities in ribosome biogenesis on human disease, ribosome biogenesis in human cells is just…
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