grant
Novel protein biomarkers of youth-onset type 2 diabetes
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 15 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY202512-20 years old17 year old17 years of age21+ years oldAccelerationActive Follow-upAddressAdolescenceAdolescentAdolescent YouthAdultAdult HumanAdult-Onset Diabetes MellitusAffectAgeAntibodiesAssayAvandiaBeta CellBioassayBiologicalBiological AssayBiological MarkersBlood PlasmaBlood ProteinsC-PeptideCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessComplications of Diabetes MellitusDataDevelopmentDiabetes ComplicationsDiabetes-Related ComplicationsDiabetic ComplicationsDiagnosisDimethylbiguanidineDimethylguanylguanidineDiseaseDisease ProgressionDisorderDisproportionate number of femalesDisproportionate number of womenDisproportionately affects femalesDisproportionately affects womenDisproportionately impacts femalesDisproportionately impacts womenDisproportionately in femalesDisproportionately in womenDysfunctionEnrollmentEthnic OriginEthnicityFailureFastingFollow-Up StudiesFollowup StudiesFunctional disorderFutureGenesGeneticGenotypeGlycohemoglobin AGlycosylated hemoglobin AHb A1Hb A1a+bHb A1cHbA1HbA1cHealth CareHealth Care CostsHealth CostsHemoglobin A(1)Humulin RHyperglycemiaInsulinInsulin CellInsulin ResistanceInsulin Secreting CellKetosis-Resistant Diabetes MellitusKnowledgeLate-Onset DisorderLinkLong-term cohortLongitudinal cohortMapsMaturity-Onset Diabetes MellitusMeasurementMeasuresMediatorMendelian randomizationMetforminMethodsMicrovascular DysfunctionModelingMorbidityMorbidity - disease rateMulti-Ethnic Study of AtherosclerosisN,N-dimethyl-imidodicarbonimidic diamideNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin ROGTTObesityObservation researchObservation studyObservational StudyObservational researchOligoOligonucleotidesOnset of illnessOralOral Glucose Tolerance TestOutcomeParticipantPathway interactionsPerformancePhenotypePhysiopathologyPlasmaPlasma SerumPopulationPredicting RiskPrognostic MarkerProteinsProteomeProteomicsPubertyQTLQuantitative Trait LociRaceRacesRandomizedRandomized, Controlled TrialsRegular InsulinReticuloendothelial System, Serum, PlasmaRiskRisk FactorsSamplingSedentary behaviorSedentary life-styleSeminalSlow-Onset Diabetes MellitusStable Diabetes MellitusSubcellular ProcessT2 DMT2DT2DMTechnologyTimeType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesYouthYouth 10-21active followupadiposityadolescence (12-20)adult onset diabetesadult youthadulthoodage 17 yearsage associatedage correlatedage dependentage groupage linkedage relatedage specificagedagesantibody conjugatebeta cell developmentbio-markersbiologicbiologic markerbiomarkerbiomarker identificationcartilage link proteincirculating biomarkerscirculating markerscohortconnecting peptidecorpulencedevelopmentaldisease onsetdisorder onseteffective therapyeffective treatmentendocrine pancreas developmentenrollexperimentexperimental researchexperimental studyexperimentsfastedfastsfemale biasfemale predominancefemale preponderancefollow upfollow-upfollowed upfollowupforecasting riskgene locusgenetic architecturegenetic locusgenomic locationgenomic locusglycemic controlhemoglobin A1chyperglycemicidentification of biomarkersidentification of new biomarkersimprovedindexinginnovateinnovationinnovativeinsightinsulin resistantinsulin toleranceislet developmentjuvenilejuvenile humanketosis resistant diabeteslate disease onsetlate onset disorderlife style interventionlifestyle interventionlink proteinlow-frequency mutationmacrovascular complicationmacrovascular diseasemarker identificationmaturity onset diabetesmicrovascular complicationsmicrovascular diseasemortalitymulti-ethnicmultiethnicnew markernew technologynovelnovel biomarkernovel markernovel technologiesoligospathophysiologypathwaypredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskpredominance in femalespredominance in womenprognostic biomarkerprognostic indicatorprospectiveprotein biomarkersprotein markersracialracial backgroundracial originrandomisationrandomizationrandomized control studyrandomized control trialrandomized, controlled studyrandomly assignedrare allelerare mutationrare variantrisk predictionrisk predictionsrosiglitazonesedentary lifestyleseventeen year oldseventeen years of agesexsmall vessel diseasetargeted biomarkertargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettraittreatment strategytype 2 DMtype II DMtype two diabeteswomen's predominancewomen's preponderanceyoung adultyoung adult ageyoung adulthoodyouth ageβ-cellβ-cellsβCell
Description preview
PROJECT SUMMARY
The effective treatment of youth-onset type 2 diabetes (YOT2D), with rising rates and an aggressive disease
course that causes morbidity and mortality in young adulthood, is a healthcare priority. Our ability to develop
treatments, however, is limited by our incomplete understanding of what drives this rapid progression.
Proteomics…
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