grant
Novel Posttranslational Modifications in Adipose Biology
NIHUS FederalResearch GrantFY202521+ years oldAPF-1ATP-Dependent Proteolysis Factor 1AdipocytesAdipose CellAdipose tissueAdultAdult HumanAutoregulationBiochemicalBiologicalBiological FunctionBiological ProcessBiologyBiotinylationBody fatBrown Adipose TissueBrown FatCUL3CUL3 geneCancersCardiometabolic DiseaseCardiometabolic DisorderCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessCullin Domain ProteinCullin Family GeneCullin Family ProteinCullin ProteinsCullinsDataDysfunctionE3 LigaseE3 Ubiquitin LigaseEndocrine GlandsEndocrine OrgansEnergy ExpenditureEnergy MetabolismEnzyme GeneEnzymesEquilibriumFamily memberFat CellsFatsFatty TissueFatty acid glycerol estersFunctional disorderGene TranscriptionGenetic TranscriptionHMG-20HealthHeart failureHeat ProductionHibernating GlandHigh Fat DietHigh Mobility Protein 20HomeostasisHumanImpairmentInflammationInsulin ResistanceIntracellular Communication and SignalingKIAA0617KnowledgeLigaseLigase GeneLinkLipocytesLipodystrophyMaintenanceMalignant NeoplasmsMalignant TumorMature LipocyteMature fat cellMediatingMetabolicMetabolic DiseasesMetabolic DisorderMiceMice MammalsMitochondriaMitochondrial ProteinsModern ManModificationMolecularMonoamine OxidaseMurineMusObesityOrganismOxidation-ReductionPathologicPhenocopyPhysiological HomeostasisPhysiopathologyPlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProductionProtein ModificationProteinsProteomeProteomicsRNA ExpressionRedoxResearchRespirationRoleSignal TransductionSignal Transduction SystemsSignalingSiteSubcellular ProcessSynthetasesTestingThermogenesisThesaurismosisTranscriptionTyramine OxidaseUbiquitilationUbiquitinUbiquitin Ligase Component GeneUbiquitin Ligase GeneUbiquitin Like ProteinsUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationadiposeadiposityadrenalin oxidaseadulthoodbalancebalance functionbiologicbiological signal transductioncardiac failurecellular targetingcorpulencediet-associated obesitydiet-induced obesitydiet-related obesityenergy balancefeedingimprovedinsightinsulin resistantinsulin toleranceliving systemmalignancymetabolism disordermitochondrialmitochondrial dysfunctionneoplasm/cancernovelobesity interventionobesity preventionobesity therapyobesity treatmentoxidation reduction reactionpathophysiologypharmacologicprevent obesityprotein homeostasisproteostasisrespiratory mechanismscaffoldscaffoldingsocial roletyraminaseubiquinationubiquitin conjugationubiquitin ligaseubiquitin-protein ligasewhite adipose tissueyellow adipose tissue
Description preview
Project Summary
Metabolic health depends on maintaining normal mass and function of adipose tissue (AT). Accumulation of
excess body fat or pathological loss of AT is associated with insulin resistance and cardiometabolic diseases.
White and brown adipose tissues act together to maintain a balance between fat accumulation and energy
expenditure.…
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