grant
Novel oxidative pathway targets microglia in Alzheimer's disease
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 15 Aug 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAdhesionsAffectAge related macular degenerationAge-Related MaculopathyAldehydesAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's brainAlzheimer's disease brainAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAmentiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnimal ModelAnimal Models and Related StudiesAβBiologyBrainBrain Nervous SystemCell AdhesionCell IsolationCell SegregationCell SeparationCell Separation TechnologyCellular AdhesionChemicalsCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexDNA mutationDegenerative Neurologic DisordersDementiaDevelopmentDiseaseDisease ProgressionDisorderDisturbance in cognitionDysfunctionEconomic BurdenEncephalonEventExposure toFunctional disorderGenetic ChangeGenetic defectGenetic mutationGliosisHortega cellHumanHuman PathologyImpaired cognitionIn VitroIntegrin-mediated Cell AdhesionIntegrin-mediated Cell Adhesion PathwayInterventionLeadLeukocyte Adhesion DeficiencyLigandsLinkLipid PeroxidationLipidsMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodsMiceMice MammalsMicrogliaModelingModern ManModificationMolecularMonitorMurineMusMutateMutationMyeloid CellsNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationOutcomeOxidative StressOxidative Stress Induced Gene Expression Via Nrf2Oxidative Stress PathwayPathologicPathologyPathway interactionsPatientsPb elementPhagocytosisPhysiopathologyPolyunsaturated Fatty AcidsPopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreventionPrimary Senile Degenerative DementiaProcessProtein ModificationProteinsProteomicsReceptor ProteinReportingResearch SpecimenRoleSOD-1SOD-1 proteinSOD1SOD1 geneSOD1 gene productSiteSpecimenSurface ProteinsSystemTechnologya beta peptideabetaage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage dependent macular degenerationage induced macular degenerationage related human diseaseage related macular diseaseage related macular dystrophyage-related diseaseage-related disorderage-related impairmentamyloid betaamyloid-b proteinbeta amyloid fibrilbrain tissuecell sortingcognitive dysfunctioncognitive lossdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentalfatty acid oxidationgenome mutationgitter cellheavy metal Pbheavy metal leadhuman diseasein vivomembrane structuremesogliamicroglial cellmicrogliocytemigrationmodel of animalmouse modelmurine modelneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronal degenerationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachoxidationoxidative damageoxidative injurypathophysiologypathwayperivascular glial cellpreservationpreventpreventingprimary degenerative dementiaprotein functionprotein structureprotein structuresproteins structurereceptorsenile dementia of the Alzheimer typesenile macular diseasesocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicssoluble amyloid precursor proteinsuperoxide dismutase 1translation to humansvesicle transportvesicular transport
Description preview
Abstract
Alzheimer's disease is the most common dementia characterized by progressive cognitive
decline. By estimates, Alzheimer's disease affects more than one-third of the population over 85,
posing a substantial socioeconomic burden. There is an apparent lack of understanding of the
molecular mechanisms of Alzheimer's disease and reported…
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