grant
Novel Neurosurgical Device for Evacuation of Intracerebral Hematoma
Organization BECKMAN RESEARCH INSTITUTE/CITY OF HOPELocation DUARTE, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AbscissionAcquired brain injuryAddressAffectAnimalsBBB crossingBasal GangliaBasal NucleiBiomedical EngineeringBlood ClottingBlood coagulationBody TissuesBrainBrain CancerBrain EdemaBrain InjuriesBrain MassBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain SwellingBrain TraumaBrain TumorsBrain hemorrhageBurr HoleCAT scanCT X RayCT XrayCT imagingCT scanCauterizationCauterizeCauteryCell BodyCellsCephalicCerebral Brain HemorrhageCerebral HemorrhageCerebral Parenchymal HemorrhageCerebral hemisphere hemorrhageCerebrum HemorrhageClinicalClinical TrialsComputed TomographyConsumptionCranialCraniotomyDWI (diffusion weighted imaging)DWI-MRIDeath RateDebridementDebulkingDevelopmentDevice or Instrument DevelopmentDevicesDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDoppler UltrasoundDrugsEncephalonExcisionExposure toExtirpationFamily suidaeFeedbackFutureGoalsHematomaHemostasisHemostatic functionHistologyHourHumanImageIn VitroIntracerebral HemorrhageIntracranial EdemaInvestigationJointsLeftLegal patentLesionLifeLobectomyLocationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant Tumor of the BrainMalignant neoplasm of brainMeasuresMechanicsMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMethodologyMethodsMinimal Access Surgical ProceduresMinimally Invasive Surgical ProceduresModelingModern ManModificationMorbidityMorbidity - disease rateMotionNMR ImagingNMR TomographyNervous System PhysiologyNeurologic functionNeurological SurgeryNeurological functionNeurosurgical ProceduresNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresPainPainfulPatentsPatientsPharmaceutical PreparationsPigsPositionPositioning AttributePostoperativePostoperative PeriodPreparationPreventative measurePreventive measureProceduresPublic HealthRemovalResidualResidual stateRoboticsRotationSafetyScientistSideSkullSuidaeSupratentorialSurfaceSurgeonSurgicalSurgical InterventionsSurgical ManagementSurgical ProcedureSurgical RemovalSwineSystemTechniquesTechnologyTestingTherapeuticTimeTissuesTomodensitometryTraumatic Brain InjuryTrephine holeTumor DebulkingVisualizationX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyZeugmatographyalternative treatmentaspiratebio-engineeredbio-engineersbioengineeringbiological engineeringbleeding in brainblood-brain barrier crossingbloodbrain barrier crossingbrain damagebrain surgerybrain tissuebrain-injuredcatscanco-morbidco-morbiditycomorbiditycomparable efficacycomparative efficacycompare efficacycomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycraniumcytoreductive surgerydMRIdesigndesigningdevelopmentaldevice developmentdiffusion tensor imagingdrug/agenteconomic valueefficacy testingelderly patientexperiencehemorrhagic strokeimage guidanceimage guidedimagingimprovedin vivoinstrumentinstrument developmentinterdisciplinary approachmacromoleculemanufacturemechanicmechanicalmeetingmeetingsminimally invasivemonetary valuemortality ratemortality ratiomotor controlmultidisciplinary approachnano particlenano-sized particlenanoparticlenanosized particlenervous system functionneural inflammationneuroinflammationneuroinflammatoryneurosurgerynon-contrast CTnoncontrast CTnoncontrast computed tomographynovelolder patientoperationoperationspain reductionpatient populationpig modelpiglet modelporcineporcine modelpostoperative recoverypre-clinical safetypreclinical safetypreparationsprototyperadiomicsreal-time imagesrealtime imagerecovery after surgeryrecovery following surgeryreduce painresectionrisk minimizationrobotic devicesafety and feasibilitysafety testingskillsskull incisionsocio-economicsocio-economicallysocioeconomicallysocioeconomicssubstantia albasuidsurgerysurgical cytoreductionswine modeltissue woundtraumatic brain damagetumor cytoreductiontumors in the brainultrasoundwet brainwhite matterwoundwoundingwounds
Description preview
PROJECT SUMMARY
Spontaneous supratentorial intracerebral hemorrhage (ICH) affects nearly 67,000 patients every year in the
US and is associated with a 35-50% mortality rate within a month of occurrence. In addition to preventive
measures and medical management, surgery continues to be an important part of treatment for such patients.
Currently,…
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