grant
Novel models to study dorsal root ganglion neurons in knee osteoarthritis pain
Organization UNIVERSITY OF CINCINNATILocation CINCINNATI, UNITED STATESPosted 18 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202521+ years oldAblationAddictive AnalgesicsAdultAdult HumanAffectAgeAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAnterior Cruciate LigamentAntinociceptive AgentsAntinociceptive DrugsArthritisArthroplastyAutomobile DrivingBasic ResearchBasic ScienceBehavioralBehavioral AssayBlood - brain barrier anatomyBlood-Brain BarrierBody TissuesCNS Nervous SystemCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCellsCentral Nervous SystemCephalalgiaCephalgiaCephalodyniaChemosensitizationChemosensitization/PotentiationChronicClinicalClinical PathologyCo-cultureCocultivationCocultureCoculture TechniquesCranial PainDNA RecombinationDangerousnessDataDegenerative ArthritisDegenerative polyarthritisDependenceDiseaseDisorderDoctor of PhilosophyDorsal Root GangliaDysfunctionElectrophysiologyElectrophysiology (science)EnvironmentExcitatory SynapseFiberFunctional disorderGene ExpressionGenesGeneticGenetic RecombinationGoalsHEAL InitiativeHead PainHeadacheHealthHelping End Addiction Long-termHelping to End Addiction Long-termHemato-Encephalic BarrierHumanImageImmobilizationInflammatoryInjectionsInjuryInsomniaInsomnia DisorderIntracellular Communication and SignalingInvestigationIon ChannelIonic ChannelsJobsJoint Prosthesis ImplantationJointsKneeKnee OsteoarthritisKnee arthroplastyKnee jointKnee joint replacement operationKnee replacementMedial MenisciMedial meniscus structureMediatingMedulla SpinalisMembraneMembrane ChannelsMeniscus MedialisMental DepressionMentorsMethodsMiceMice MammalsMissionModelingModern ManMurineMusNIAMSNSAIDsNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesNerveNerve CellsNerve RegenerationNerve UnitNervous SystemNeural CellNeuraxisNeuro-regenerationNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeuropathyNeurophysiology / ElectrophysiologyNeuroregenerationNociceptionNon-Steroidal Anti-Inflammatory AgentsOccupationsOperative ProceduresOperative Surgical ProceduresOpiatesOpioidOsteoarthritisOsteoarthrosisPainPain DisorderPain ResearchPainfulPathologicPathway interactionsPatientsPeripheral NervesPersonsPh.D.PhDPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePhysiopathologyPopulationPost-Procedural PainPost-operative PainPostoperative PainPotentiationProceduresProfessional PositionsProprioceptionQOLQuality of lifeRecombinationReplacement ArthroplastyResearchRodentRodentiaRodents MammalsSignal TransductionSignal Transduction SystemsSignalingSleeplessnessSourceSpinalSpinal CordSpinal GangliaSurgicalSurgical InterventionsSurgical ProcedureSwellingSystemTRPV1TRPV1 geneTechniquesTestingTherapeuticTissuesTotal Knee ReplacementTrainingTranslationsTransmissionTraumatic ArthritisTraumatic ArthropathyUniversitiesVR1 receptorViralWorkadulthoodagesalternative treatmentarthriticbiological signal transductionbloodbrain barriercapsaicin receptorcareer developmentcell culturecell cultureschronic painchronic pain conditionchronic pain disorderchronic painful conditionclinical relevanceclinically relevantcommon treatmentdegenerative joint diseasedepressiondisabilitydisabling paindorsal root gangliondrivingelectrophysiologicalexperienceglobal gene expressionglobal transcription profilehead achehigh riskhuman modelhuman tissuehypertrophic arthritisimaginginflamed jointinjuriesjoint arthroplastyjoint damagejoint inflammationjoint injuryjoint replacementjoint swellingjoint traumaknee OAknee joint OAknee joint osteoarthritisknee painknee replacement arthroplastymembrane structuremodel of humanmouse modelmurine modelnervous system regenerationneural circuitneural circuitryneural regenerationneurocircuitryneuronalneuropathicneuroregenerativenociceptivenon-steroidal anti-inflammatory drugsnovelorthopedic freezingosteoarthritis associated painosteoarthritis painpain after surgerypain killerpain medicationpain reliefpain relieverpain-related disabilitypainkillerpathophysiologypathwaypharmaceuticalpost-surgical painpost-traumatic osteoarthritispostsurgical painpre-clinicalpreclinicalpreservationpreventpreventingprogramsregenerated nerverelieve painscRNA sequencingscRNA-seqside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsuccesssurgerysynaptic circuitsynaptic circuitrytherapeutic targettissue culturetotal knee arthroplastytranscriptometranscriptomicstransient receptor potential cation channel V1translationtransmission processvanilloid receptor VR1vanilloid receptors
Description preview
PROJECT SUMMARY/ABSTRACT
Knee osteoarthritis (OA) is a leading source of disabling pain, affecting nearly 20% of US adults over 45, which
will only increase as our population ages. Although remarkable research and clinical efforts are being poured
into discovering vital disease-modifying treatments (i.e., reversing joint damage, joint…
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