grant
Novel Mechanisms Underlying the Development of Atherosclerosis
Organization HARRY S. TRUMAN MEMORIAL VA HOSPITALLocation COLUMBIA, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
VANIHUS FederalResearch GrantFY2025ACATACAT enzymeACAT-1ACAT1APOEASCVDAcetylsalicylic AcidAcute myocardial infarctAcute myocardial infarctionAcyl CoAAcyl Coenzyme AAcyl-CoA-Cholesterol AcyltransferaseAntibodiesAortaApo-EApoE proteinApolipoprotein EApoplexyApoptosisApoptosis PathwayArterial Fatty StreakArterial IntimasArteriesAspirinAtherogenicityAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueAtherosclerosisAtherosclerotic Cardiovascular DiseaseBeta Proprotein Interleukin 1BiochemicalBlood SerumBlood flowBrain Vascular AccidentC-EBP Nuclear ProteinC-EBP ProteinsC/EBPCAAT-Enhancer-Binding ProteinsCCAAT Sequence-Specific DNA-Binding ProteinsCCAAT-Enhancer-Binding ProteinsCardiac arteryCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCholesterolCholesterol AcyltransferaseCholesterol Esterifying EnzymeCholesterol EstersCholesteryl EstersChronicClinicalComplexCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoronary arteryDataDevelopmentDiseaseDisorderDown-RegulationDrugsElementsEventFatty Acyl CoAFibratesFoam CellsGeneral PopulationGeneral PublicGoalsHDL CholesterolHDL Cholesterol LipoproteinsHeart VascularHeart arteryHeart failureHigh Density Lipoprotein CholesterolHigh Fat DietHistologicHistologicallyHomologous ProteinHospital AdmissionHospitalizationHumanIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βIn VitroInflammatoryInflammatory ResponseInterleukin 1betaInterleukin-1 betaInterleukin-1βIntracellular Communication and SignalingLeiomyocyteLesionLineage TracingLipidsLong-Chain Acyl CoAMacrophageMediatingMedicationMiceMice MammalsModern ManMolecularMolecular TargetMorbidityMorbidity - disease rateMurineMusMyelogenousMyeloidMφNuclearOutcomePathway interactionsPharmaceutical PreparationsPhenotypePlayPreinterleukin 1 BetaPreventionProgrammed Cell DeathProgressive DiseaseProtein HomologProteinHomologProteinsRoleSerumSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSterol O-AcyltransferaseStrokeSubcellular ProcessTestingTherapeuticTherapeutic AgentsVascular Smooth MuscleVeteransacyl-CoA cholesterol acyltransferaseacyl-CoA cholesterol acyltransferase-1alpha-Lipoprotein Cholesterolatherogenesisatheromatosisatherosclerosis plaqueatherosclerotic coronary diseaseatherosclerotic diseaseatherosclerotic lesionsatherosclerotic plaqueatherosclerotic vascular diseasebiological signal transductionbrain attackcardiac failurecardiovascular healthcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingcerebral vascular accidentcerebrovascular accidentcirculatory systemcoronary arterial diseasedevelopmentaldrug/agenteffective therapyeffective treatmentgenetic approachgenetic strategyhigh riskimprovedin vivoinhibitorknock-downknockdownloss of functionmilitary veteranmortalitynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetolfactomedinoverexpressoverexpressionox-LDLoxidized LDLoxidized low density lipoproteinpathwaypharmacologicplaques in atherosclerosisprotein expressionsocial rolesterol O-acyltransferase 1strokedstrokestherapeutic agent developmenttherapeutic developmentvascular inflammationveteran population
Description preview
Project Summary
Coronary atherosclerosis is one of five top causes for cardiovascular (CV) hospitalization in U.S. Veterans.
Atherosclerosis is a complex and progressive disease characterized by the buildup of plaques composed of lipid-
rich foam cells, inflammatory cells, and fibrous elements in the arterial intima. Atherosclerosis is associated…
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