grant
Novel Mechanisms underlying abdominal aortic aneurysm progression
Organization UNIVERSITY OF MISSOURI-COLUMBIALocation COLUMBIA, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025(TNF)-αAPOEAbdominal Aortic AneurysmAdventitiaAdventitial CellAngIIAngiotensin IIAortaAortic DiseasesAortic RuptureApo-EApoE proteinApolipoprotein EApoptosisApoptosis PathwayArteriesAttenuatedAutoregulationBasic ResearchBasic ScienceBlood VesselsBone-Derived Transforming Growth FactorCUT&RUNCachectinCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCell SurvivalCell ViabilityCellsCellular ProliferationCellular biologyCessation of lifeCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCollagenCore FacilityDNA RecombinationDataDeathDeath RateDepositDepositionDevelopmentDiseaseDisorderDissectionDown-RegulationDrug TherapyElastasesElastinEnvironmentEquipmentEventFemaleFibroblastsFutureGenesGenetic RecombinationHistologicHistologicallyHomeostasisHumanImpairmentIn VitroInfusionInfusion proceduresIntracellular Communication and SignalingInvoluntary MuscleKO miceKinasesKnock-out MiceKnockout MiceKnowledgeLaboratoriesLeadLeiomyocyteLesionLineage TracingMacrophage-Derived TNFMedialMiceMice MammalsMilk Growth FactorMissouriModelingModern ManMolecularMonocyte-Derived TNFMurineMusNeural Crest CellNull MouseOutcomePathologicPathologyPathway interactionsPb elementPericapillary CellPericytesPerivascular CellPharmacological TreatmentPharmacotherapyPhenotypePhosphorylationPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPlatelet Transforming Growth FactorPlayPositionPositioning AttributePreventative strategyPrevention strategyPreventive strategyProgrammed Cell DeathProliferatingProtein Kinase InteractionProtein PhosphorylationProteinsPublicationsPublishingRIP3RIPK3RIPK3 geneReceptor-Interacting ProteinReceptor-Interacting Protein 3Receptor-Interacting Serine/Threonine Protein Kinase 3RecombinationRegulationResearchResearch ResourcesResourcesRoleRouget CellsRuptureRuptured Abdominal Aortic AneurysmScientific PublicationSignal TransductionSignal Transduction SystemsSignalingSmooth MuscleSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellTGF BTGF-betaTGF-βTGFbetaTGFβTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTechniquesTechnologyTestingTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransphosphorylasesTumor Necrosis FactorTumor Necrosis Factor-alphaTunica AdventitiaUniversitiesUpregulationVascular Smooth MuscleWild Type Mouseanimal facilityaortic disorderattenuateattenuatesautosomebiological signal transductioncell biologycell dedifferentiationcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingclinical applicabilityclinical applicationdevelopmentaldrug interventiondrug treatmentgenetic approachgenetic strategyheavy metal Pbheavy metal leadin vivoinfusionsloss of functionmalemortality ratemortality ratiomuscle degenerationnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnucleasepathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreservationpreventpreventingresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutically effectivetransdifferentiationvascularvascular inflammationwildtype mouse♀♂
Description preview
Summary/Abstract
Abdominal aortic aneurysm (AAA) is a potentially lethal disease that lacks pharmacological treatment. Although
vascular inflammation is the initial event leading to AAA formation, aorta rupture due to artery wall weakening
is responsible for the high mortality rate in this silent killer. Aortic wall weakening in AAA is primarily…
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