grant
Novel mechanisms and vascular interactions mediating the cardiometabolic benefits of exercise
Organization CHARLES R. DREW UNIVERSITY OF MED & SCILocation LOS ANGELES, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202521+ years oldASCVDAdipose tissueAdultAdult HumanAmericanAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntidiabetic HormoneAortaApoplexyArteriesAtherosclerosisAtherosclerotic Cardiovascular DiseaseBODIPYBP homeostasisBP regulationBindingBiogenesisBioinformaticsBiologyBlood PlasmaBlood VesselsBlood flowBody TissuesBrain Vascular AccidentCardiacCardiac ChronotropismCardiometabolic DiseaseCardiometabolic DisorderCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular MechanotransductionCellular PhysiologyCellular ProcessCellular biologyCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronic disabilityCirculationCo-cultureCocultivationCocultureCoculture TechniquesColoring AgentsConsumptionCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoupledD-GlucoseDNA Molecular BiologyDataDescending aortaDevelopmentDextroseDisabled PersonsDisabled PopulationDrug ScreeningDyesDysfunctionEndocrine Gland SecretionEndothelial CellsEndotheliumExerciseExposure toFaceFatsFatty AcidsFatty TissueFatty acid glycerol estersFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsG-ProteinsGLP-1GPCRGTP-Binding ProteinsGTP-Regulatory ProteinsGeneralized GrowthGenesGlp-1GlucagonGlucoseGlukagonGoalsGrowthGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHG-FactorHandicappedHealthHealth Care SystemsHeartHeart RateHeart VascularHeat ProductionHepaticHigh Fat DietHormonesHumulin RHyperglycemic-Glycogenolytic FactorHypertensionImageImmunoblottingIn VitroIndividualIndividuals with physical disabilitiesInflammationInjectionsInsulinIntermediary MetabolismInterventionLeiomyocyteLigandsLinoleic AcidsLipaseLipidsLipolysisLiverMechanical Signal TransductionMechanicsMechanosensory TransductionMediatingMedicineMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsModelingModernizationMolecularMolecular BiologyMolecular InteractionMorbidityMorbidity - disease rateMurineMusNasalNasal Passages NoseNational Institutes of HealthNoseNovolin RObesityOilsOlfactory EpitheliumOrganOrigin of LifeOxidative StressPathway interactionsPeople with DisabilitiesPerformancePeripheral arterial diseasePersistent disabilityPersons with DisabilitiesPersons with Physical DisabilitiesPhysical ExercisePhysical activityPhysiologicPhysiologic pulsePhysiologicalPhysiopathologyPlasmaPlasma SerumPositionPositioning AttributePreventionPropertyPublishingPulseQOLQuality of lifeReceptor ProteinRecommendationRegular InsulinReportingResearchRespiratory System, Nose, Nasal PassagesReticuloendothelial System, Serum, PlasmaRoleRunningScienceSedentary behaviorSedentary life-styleShort interfering RNASkeletal MuscleSmall Interfering RNASmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSocietiesStearate DesaturaseStearoyl-CoA DesaturaseStearyl-CoA DesaturaseStretchingStrokeSubcellular ProcessSystemTestingTherapeuticTherapeutic HormoneTherapeutic InterventionThermogenesisTissue GrowthTissuesTransducersTransfectionTriacylglycerol HydrolaseTriacylglycerol LipaseTriacylglycerol acylhydrolaseTributyrinaseTriglyceridaseTriglyceride LipaseTriolean HydrolaseUnited States National Institutes of HealthUniversitiesVascular EndotheliumVascular Hypertensive DiseaseVascular Hypertensive DisorderVascular Smooth MuscleVoluntary MuscleWestern BlottingWestern Immunoblottingadipogenesisadiposeadiposityadulthoodanaerobic glycolysisaortic archatheromatosisatherosclerotic coronary diseaseatherosclerotic diseaseatherosclerotic vascular diseaseazelaic acidblood pressure homeostasisblood pressure regulationbrain attackcardiometaboliccardiometabolismcardiovascular disordercell biologycell typecerebral vascular accidentcerebrovascular accidentcirculatory systemconfocal imagingcoronary arterial diseasecorpulencedelta-9 Desaturasedesigndesigningdevelopmentaldisabled individualdisabled peopleexercise trainingfacesfacialfatty acid oxidationglucagon-like peptide 1hepatic body systemhepatic organ systemhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimagingimprovedin vivoindividuals with disabilitiesintervention therapylipid biosynthesislipogenesismechanicmechanicalmechanical forcemechanosensingmechanotransductionmetabolism measurementmetabolomicsmetabonomicsmortalitymultiomicsmultiple omicsnonanedioic acidnovelolfactory receptorontogenypanomicspathophysiologypathwayperipheral artery diseasepreventpreventingprotein blottingprotein expressionreceptorregulate BPregulate blood pressureresponsesedentarysedentary lifestyleshear stresssiRNAsocial rolestrokedstrokestreadmilltributyrasevascularvascular inflammationwhite adipose tissueyellow adipose tissue
Description preview
Cardiovascular diseases, including coronary artery disease, stroke, and peripheral arterial disease predispose individuals to develop chronic disability, compromise life quality and increase burden on the healthcare system. Physical exercise modulates metabolic processes in multiple organs to ameliorate cardiovascular disorders. After decades of…
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