grant
Novel Lymphocyte Chemoattractant Receptor and Ligand
Organization PALO ALTO VETERANS INSTIT FOR RESEARCHLocation PALO ALTO, UNITED STATESPosted 23 Feb 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AddressAdhesionsAssayAutoimmuneAutoimmune DiseasesAutoregulationB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBioassayBiological AssayBloodBlood Reticuloendothelial SystemBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemC-C CKR-9C-terminalCC Chemokine Receptor 10 GeneCC-CKR-9CCL25CCL25 geneCCR-9CCR10CCR9CCR9 geneCHEMERINRCHEMR23CMKLR1CMKLR1 geneCancer ControlCancer Control ScienceCell BodyCell Communication and SignalingCell SignalingCellsChemerin ReceptorChemoattractant ReceptorChemoattractantsChemokine Like Receptor 1Chemokine, CC Motif, Ligand 25Chemotactic CytokinesChemotactic FactorsChemotactic Peptide ReceptorChemotaxinsChemotaxisChimeraChimera organismChronicClinicalColonDataDevelopmentDiseaseDisorderEnvironmental FactorEnvironmental Risk FactorEpithelial CellsEpitheliumF-Chemotactic Peptide ReceptorFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFormyl Peptide ReceptorsG Protein-Complex ReceptorG Protein-Coupled Receptor 15G Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGPR-9-6GPR15GPR15 geneGPR2GPR2 geneGamma-delta T cellsGenitourinaryGenitourinary systemGlandGoalsHomeostasisHomingHomologous Chemotactic CytokinesHumanImmuneImmune TargetingImmune responseImmune systemImmunesImmunityIn VitroInfectionInflammationInflammatoryIntercrinesIntestinalIntestinesIntracellular Communication and SignalingInvadedKnowledgeLigandsLungLung Respiratory SystemLymphatic cellLymphocyteLymphocyte BiologyLymphocyticLymphoidMediatingMiceMice MammalsModelingModern ManMolecular InteractionMucosaMucosal Immune SystemMucosal TissueMucous MembraneMurineMusMyeloid CellsN-Formylmethionyl Peptide ReceptorN-formyl Hexapeptide ReceptorNatureOrganOrphanPancreasPancreaticPathologyPathway interactionsPeptidesPhysiological HomeostasisPopulationPopulation StudyPreventiveProgenitor CellsPropertyReceptor ActivationReceptor ProteinRegulationRoleSCYA25SIS cytokinesSalivary GlandsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSkinSmall Inducible Cytokine Subfamily A, Member 25Small IntestinesSpecificityStomachStructureSystemT-Cell ActivationT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsTECKTestingTherapeuticThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemThymus-Expressed ChemokineTissuesTranslatingUpper GIUpper GI TractUpper Gastrointestinal TractUpper digestive tract structureUrogenitalUrogenital SystemVariantVariationactivate T cellsautoimmune conditionautoimmune disorderautoimmune inflammationautoimmunity diseasebiological signal transductionbowelchemoattractant cytokinechemokinechimerascomplement chemotactic factorcurative interventioncurative therapeuticcurative therapycurative treatmentscytokinedesigndesigningdevelop therapydevelopmentalenvironmental riskfMet-Leu-Phe receptorflow cytophotometrygastricgenitourinary tracthigh dimensionalityhost responseimmune reconstitutionimmune system responseimmunoresponseimprintimprovedin vivoinnovateinnovationinnovativeintervention developmentlymph celllymphocyte traffickingmigrationmucosal sitemutantneoplasticnew approachesnovelnovel approachesnovel strategiesnovel strategypathogenpathwaypopulation research studypopulation surveypopulation-based studypopulation-level studyprimary lymphatic organprimary lymphoid organpulmonaryreceptorreceptor bindingreceptor boundreceptor expressionrecruitresponsescRNA sequencingscRNA-seqsecondary lymph organsecondary lymphatic organsecondary lymphoid organselective expressionselectively expressedsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall bowelsocial rolestem cellstherapy developmentthymus derived lymphocytetooltraffickingtreatment developmenttreatment strategyurogenital tractvaccine strategyγδ T cellsγδT cells
Description preview
PROJECT SUMMARY/ABSTRACT
The immune system at mucosal sites has evolved to mediate rapid immunity to invading pathogens, while
limiting over-reactive responses that drive chronic inflammation. Mechanisms of lymphocyte trafficking are
essential for the function and systemic integration of the immune system, and in particular for targeting immune…
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