grant
Novel Integrative Analysis of Microbiome and Host Genetics in Childhood Asthma Research
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 17 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20250-11 years oldAddressAdoptionAllergyAreaArtifactsAsthmaAsthma in ChildrenAwarenessBirthBronchial AsthmaCausalityCell Communication and SignalingCell SignalingChildChild HealthChild YouthChildhood AsthmaChildren (0-21)CollectionComplexComputational toolkitComputer softwareDataData BanksData SetDatabanksDevelopmentDiseaseDisorderEducationEducational aspectsEnvironmentEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorEtiologyFundingGI microbiomeGWA studyGWASGeneticGenetic DiversityGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic VariationGenetic propensityGenetic studyGenotypeGeographyHealth Care CostsHealth CostsHigh PrevalenceHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHost FactorHost Factor ProteinHuman GeneticsHuman GenomeHuman MicrobiomeImmuneImmune systemImmunesIndividualInfantInherited PredispositionInherited SusceptibilityIntegration Host FactorsIntermediary MetabolismIntracellular Communication and SignalingInvestigationLinkLiteratureMendelian randomizationMeta-AnalysisMetabolic ProcessesMetabolismMethodologyMethodsMorphologic artifactsMultiple Birth OffspringMultiple BirthsNasalNasal Passages NoseNational Institutes of HealthNatureNoseOutcomeParturitionPediatric asthmaPhenotypePhysiologicPhysiologicalPlayPositionPositioning AttributePreventative strategyPrevention strategyPreventive strategyPublic HealthReproducibilityResearchRespiratory System, Nose, Nasal PassagesRiskRoleSamplingSeverity of illnessShapesSignal TransductionSignal Transduction SystemsSignalingSoftwareStatistical MethodsTechnologyTestingUnited States National Institutes of HealthValidationVariantVariationanalyze microbiomeasthma preventionbiological signal transductioncausationcohortcomputational toolboxcomputational toolscomputational toolsetcomputerized toolsdata depositorydata diversitydata repositorydata set repositorydataset repositorydevelopmentaldigestive tract microbiomedisease causationdisease severitydiverse dataenteric microbiomeenvironmental riskfeature selectiongastrointestinal microbiomegenetic associationgenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedgenome wide analysisgenome wide associationgenome wide association scangenome wide association studygenome wide studiesgenome-wide analysisgenome-wide identificationgenomewide association scangenomewide association studygut microbiomegut microbiome of infantgut-associated microbiomehuman whole genomehuman-associated microbiomeinfant gut microbiomeintestinal biomeintestinal microbiomekidsmicrobialmicrobial compositionmicrobiomemicrobiome analysismicrobiome community compositionmicrobiome compositionmicrobiome interventionmicrobiome species compositionmicrobiome structuremicrobiome therapeuticsmicrobiome therapymicrobiome treatmentmicrobiome-based interventionmicrobiome-based therapeuticmicrobiome-based therapymicrobiome-based treatmentmicroorganismnasal microbiomeneonate gut microbiomenewborn gut microbiomenovelsemiparametricsimulationsinonasal microbiomesocial rolestatistic methodsstatisticstherapeutic targettreatment strategyuser-friendlyvalidationswhole genome association analysiswhole genome association studyyoungster
Description preview
Project Summary
Childhood asthma poses a significant public health burden due to its high prevalence, associated
healthcare costs, and long-term impacts on children's health and development. The human
microbiome has been associated with asthma phenotypes, endotypes, and disease severity,
positioning it as a potential therapeutic target for asthma…
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