grant
Novel Early Retinal Imaging Biomarkers for Treating Later Spatial Memory Loss in Experimental Alzheimer's Disease
Organization WAYNE STATE UNIVERSITYLocation DETROIT, UNITED STATESPosted 15 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAD pathologyAbscissionAgeAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease riskAlzheimer's pathologyAlzheimer's patientAlzheimers DementiaAmentiaAmmon HornAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAppearanceAssayAβBioassayBiological AssayBiological MarkersBrainBrain Nervous SystemCa Release Channel-Ryanodine ReceptorCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCalcium-Ryanodine Receptor ComplexCoenzyme Q-Cytochrome-c ReductaseCoenzyme QH2-Cytochrome-c ReductaseCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplex IIIContrast SensitivityCornu AmmonisCytochrome b-c2 OxidoreductaseDementiaDepositDepositionDihydroubiquinone-Cytochrome-c ReductaseDiseaseDisorderDisturbance in cognitionDoppler OCTDrug TargetingDrug usageDrugsDysfunctionElectron Transport Complex IIIEncephalonEndoplasmic ReticulumErgastoplasmEvaluationExcisionExtirpationFemaleFunctional disorderGlutamatesGoalsHippocampusHydrogen OxideHyperactivityImpaired cognitionImpairmentIn SituIndividualL-GlutamateLaboratoriesLearningLeftLightLinkMeasuresMedicationMemory DeficitMemory LossMemory impairmentMethodsMiceMice MammalsMitochondriaMorbidityMorbidity - disease rateMurineMusNamesNerve CellsNerve UnitNervous SystemNeural CellNeuritic PlaquesNeurocyteNeurofibrillary TanglesNeurologic Body SystemNeurologic Organ SystemNeuronsOCT TomographyOptical Coherence TomographyPatientsPharmaceutical PreparationsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiopathologyPrediction of Response to TherapyPrimary Senile Degenerative DementiaProxyPublic HealthQH(2)-Cytochrome-c ReductaseQH(2)-Ferricytochrome-c OxidoreductaseRemovalReportingResearchResolutionRetinaRisk FactorsRodRyanodine ReceptorRyanodine Receptor Calcium Release ChannelSenile PlaquesSurgical RemovalSynapsesSynapticTestingTextTherapeuticTimeTreatment EfficacyUbihydroquinone-Cytochrome-c ReductaseUbiquinol-Cytochrome-c ReductaseUbiquinol-ferricytochrome-c oxidoreductaseUbiquinone-Cytochrome b-c2 OxidoreductaseVDCCVisual Contrast SensitivityVisual ReceptorVoltage-Dependent Calcium ChannelsWaterWhole-Cell RecordingsWild Type Mousea beta peptideabetaagesalzheimer modelalzheimer riskamyloid betaamyloid beta plaqueamyloid-b plaqueamyloid-b proteinaβ plaquesbeta amyloid fibrilbio-markersbiologic markerbiomarkerbiomarker drivenbiomarker signaturecognitive dysfunctioncognitive losscored plaquecrosslinkdiffuse plaquedrug usedrug/agentexperiencefallsglutamatergichippocampalimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerindexingintervention efficacymalememory declinememory dysfunctionmild cognitive disordermild cognitive impairmentmitochondrialnamenamednamingneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuronalnoveloptical Doppler tomographyoptical coherence Doppler tomographyp-taup-τpathophysiologypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasephospho-tauphospho-τphosphorylated taupost-translational modification of tauposttranslational modification of taupredict therapeutic responsepredict therapy responsepreventpreventingprimary degenerative dementiarate of changeresectionresolutionsresponseretinal imagingsenile dementia of the Alzheimer typesoluble amyloid precursor proteinspatial memorysynapsetangletau phosphorylationtau posttranslational modificationtau-1therapeutic efficacytherapy efficacytherapy predictiontreatment predictiontreatment response predictionwildtype mouseτ phosphorylation♀♂
Description preview
Therapeutically delaying the progressive decline in cognition in patients with Alzheimer’s
disease (AD) would transform AD into a manageable morbidity, a goal that has not been
achieved using drugs targeted to β-amyloid (Aβ) plaque deposition. Accumulating results
indicate that cognitive loss (linked to circuit / synaptic dysfunction) and…
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