grant

Novel biomarkers and pathways of persistent endometriosis-associated pain across the life course

Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 23 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202612-20 years old21+ years oldAbscissionAcuteAdolescenceAdolescentAdolescent YouthAdultAdult HumanAdult femalesAdult womenAffectAgeAnalgesia TestsAscitic FluidBackBasic ResearchBasic ScienceBiologicalBiological MarkersBiological Specimen BanksBiological Substance BanksBladderBladder Urinary SystemBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesCNS Nervous SystemCannot achieve a pregnancyCentral Nervous SystemChronicClinicalComplexDataDevelopmentDifficulty conceivingDiseaseDisorderDorsumEconomicsEndocrine TherapyEndometrialExcisionExtirpationFatigueFemaleFemale HealthFemales in adulthoodFunctional MRIFunctional Magnetic Resonance ImagingHigh Risk WomanHormonal TherapyInfertilityInflammatoryInterventionIntestinalIntestinesIntractable PainLack of EnergyLesionLifeLife CycleLife Cycle StagesLinkLong-term cohortLong-term painLongitudinal cohortMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMichiganNMR ImagingNMR TomographyNeuraxisNeurobiologyNeuroimmuneNociception TestsNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresPainPain AssessmentPain MeasurementPain measurePainfulParticipantPathway interactionsPatient Self-ReportPatientsPelvic PainPeritoneal EffusionPeritoneal FluidPersistent painPhenotypePlasmaPlasma ProteinsPlasma SerumPrognostic MarkerProteinsProteomicsProtocolProtocols documentationQOLQuality of lifeQuestionnairesRefractoryRefractory PainRemovalReproducibilityReproductive HealthResearchResistanceReticuloendothelial System, Serum, PlasmaRiskSamplingSelection for TreatmentsSelf-ReportSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSymptomsTestingTherapeutic HormoneTimeTissuesTreatment outcomeUniversitiesUterusWomanWomen in adulthoodWomen's HealthZeugmatographyadolescence (12-20)adolescent womanadolescent womenadulthoodagesassociated symptomat-risk femalesat-risk womenbio-markersbiologicbiologic markerbiological specimen repositorybiomarkerbiomarker identificationbiosample repositorybiospecimen bankbiospecimen repositorybowelcartilage link proteinchildbearing agechronic pelvic floor painchronic pelvic painchronic pelvic pain syndromeclinical practiceco-morbid symptomco-occuring symptomcohortcommon treatmentcomorbid symptomconcurrent symptomconstant paincooccuring symptomcostdevelopmentaleconomicendocrine treatmentendometriosisexperiencefMRIfemales at high riskfertile agefertility cessationfertility losshigh risk femaleshormonal treatmenthormone therapyhormone treatmentidentification of biomarkersidentification of new biomarkersinfertileinflammation markerinflammatory markerinnovateinnovationinnovativeintractable pain syndromejuvenilejuvenile humanlasting painlife courselink proteinmarker identificationneural imagingneuro-imagingneurobiologicalneuroimagingneurological imagingnew markernovel biomarkernovel markeron-going painongoing painpain assaypathwaypelvic myofascial painprognostic biomarkerprognostic indicatorreproductive agereproductive yearsresectionresistantselection of treatmentspecimen bankspecimen repositorystandard carestandard treatmentsurgerysymptom associationsymptom comorbiditytherapy selectiontreatment selectionurinary bladderwombwomen at high riskyoung woman
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ABSTRACT. Endometriosis is a chronic inflammatory condition defined by the presence of endometrial-like
tissue outside the uterus that often presents with pain and infertility, affecting approximately 10% of reproductive

aged women. While some women respond well to hormonal therapy or surgical treatment, others do not and are

plagued with…

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Novel biomarkers and pathways of persistent endometriosis-associated pain across the life course — UNIVERSITY OF MICHIGA | Dev Procure