grant
Novel approaches to improve comprehensive profiling of the epigenome and epitranscriptome
Organization UNIVERSITY OF CALIFORNIA SANTA CRUZLocation SANTA CRUZ, UNITED STATESPosted 18 Aug 2020Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AdoptionAffectAreaBaker's YeastBenchmarkingBest Practice AnalysisBrewer's YeastCell BodyCell Membrane PermeabilityCellsChromatinCommunitiesComputational toolkitComputing MethodologiesDNADNA FingerprintingDNA ModificationDNA Modification ProcessDNA ProfilingDNA TypingDeoxyribonucleic AcidDetectionDiseaseDisorderEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFutureGene TranscriptionGenesGenetic FingerprintingsGenetic TranscriptionGenomeHumanHuman GenomeIsoformsLengthMethodologyMethodsModern ManModificationNon-Polyadenylated RNANucleotidesProcessProtein IsoformsProtocolProtocols documentationRNARNA EditingRNA ExpressionRNA Gene ProductsRNA ProcessingRNA SequencesRNA analysisRNA, Messenger, EditingRegulationRibonucleic AcidS cerevisiaeS. cerevisiaeSaccharomyces cerevisiaeTechnologyTissue SampleTranscriptTranscriptionWorkYeastsbenchmarkchromatin remodelingcomputational methodologycomputational methodscomputational toolboxcomputational toolscomputational toolsetcomputer based methodcomputer methodscomputerized toolscomputing methodepigeneticallyepigenomeepigenome profilingepigenomic profilingepigenomicsepitranscriptomeepitranscriptomicsgenetic informationgenome scalegenome-widegenomewidehuman whole genomeimprovedin vivoinsightlong read seqlong-read sequencinglong-read transcript sequencingmembrane permeabilitymutantnew approachesnovelnovel approachesnovel strategiesnovel strategysmall moleculeuser-friendly
Description preview
Project Summary
In 2022, advances from long-read sequencing methods facilitated the completion of a complete human
genome sequence. To interpret the genetic information from human genome sequences and understand how
cells regulate which parts of the genome are transcribed, how RNA transcripts are processed, and how these
processes are dysregulated…
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