grant
Novel applications and translation of [18F]hGTS13, a system xc- specific radiopharmaceutical
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Amino Acid ChannelAmino Acid Transport SystemsAmino Acid TransporterAnabolismAntioxidantsApoptosisApoptosis PathwayAtomic MedicineAttenuatedAutoregulationBiodistributionBiologyCAT scanCT X RayCT XrayCT imagingCT scanCancer BiologyCancer DetectionCancer InductionCancer ModelCancer TreatmentCancer cell lineCancerModelCancersCaspaseCaspase GeneCell BodyCell Culture TechniquesCell DeathCell Membrane LipidsCell membraneCell-Death ProteaseCellsCessation of lifeClinicalClinical ResearchClinical StudyCommon Rat StrainsCommunitiesComputed TomographyCysteineCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesCystineCytoplasmic MembraneDeathDependenceDevelopmentDiscipline of Nuclear MedicineDoseDrug KineticsDrug MonitoringDrug TherapyDrug resistanceDrugsEquilibriumExhibitsFatty Acid HydroperoxidesFe elementFe metabolismFemaleFoundationsGenerationsGlutamatesGlutathioneGoalsHalf-CystineHeterograftHeterologous TransplantationHomeostasisHomoHumanHuman VolunteersICE-like proteaseIND FilingIND applicationIND packageIND submissionImmuneImmunesIn VitroInflammationInvestigationInvestigational DrugsInvestigational New Drug ApplicationInvestigational New DrugsInvestigatorsIronKnowledgeL-CysteineL-CystineL-GlutamateLipid HydroperoxideLipid PeroxidesLipoperoxidesMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMediatingMedicationMembrane LipidsMembrane Transport ProteinsMembrane TransportersModelingModern ManMonitorMorphologyNuclear MedicineOxidation-ReductionOxidative StressPETPET ScanPET imagingPET/CTPET/CT scanPETSCANPETTPathway interactionsPatient SelectionPharmaceutical PreparationsPharmacokineticsPharmacological TreatmentPharmacotherapyPhysiological HomeostasisPlasma MembranePlayPositionPositioning AttributePositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPre-Clinical ModelPreclinical ModelsPrediction of Response to TherapyPredispositionProcessProductionProgrammed Cell DeathPulmonary CancerPulmonary malignant NeoplasmQuality ControlRad.-PETRadiation ChemistryRadiation DosimetryRadiochemistryRadiology / Radiation Biology / Nuclear MedicineRadiometryRadiopharmaceutical CompoundRadiopharmaceuticalsRatRats MammalsRattusRedoxRegulationReportingResearch PersonnelResearchersResistanceRoleSafetyShort interfering RNASmall Interfering RNASpecificitySusceptibilitySystemTestingTherapeuticTomodensitometryToxic effectToxicitiesTracerTranslatingTranslationsTumor VolumeUniversitiesVisualizationWorkX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXenograftXenograft procedureXenotransplantationXray CAT scanXray Computed TomographyXray computerized tomographyanti-cancer researchanti-cancer therapyantiporterattenuateattenuatesbalancebalance functionbiosynthesiscancer cellcancer imagingcancer researchcancer therapycancer-directed therapycarcinogenesiscatscancell culturecell culturescell typeclinical investigationclinical relevanceclinical translationclinically relevantclinically translatablecomparativecomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycystein proteasecystein proteinasecysteine endopeptidasedevelopmentaldosimetrydrug interventiondrug mechanismdrug resistantdrug treatmentdrug/agentfirst in manfirst-in-humangamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycineglutamatergicglutathione peroxidasehealthy volunteerimage-based methodimaging biomarkerimaging markerimaging methodimaging modalityimaging systemimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedin vivoinhibitorinterestiron metabolismknock-downknockdownlipid peroxidelung cancermalemalignancymolecular imagingmolecule imagingnecrocytosisneoplasm/cancernon-contrast CTnon-invasive imagingnoncontrast CTnoncontrast computed tomographynoninvasive imagingnoveloncologic imagingoncology imagingoxidation reduction reactionoxidative damageoxidative injurypathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsplasmalemmapositron emission computed tomographypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypredict responsivenesspredict therapeutic responsepredict therapy responsepredicting responseradioactive drugsradioassayradiolabelradiolabelsradiotherapeutic drugsradiotracerresistance to Drugresistantresistant to DrugsiRNAsocial roletherapeutic targettherapy predictiontranslationtreatment effecttreatment predictiontreatment response predictiontumortumor imaginguptakexeno-transplantxeno-transplantation♀♂
Description preview
ABSTRACT.
Ferroptosis is a form of regulated cell death defined by the iron-dependent accumulation of membrane lipid
peroxides that results in oxidative damage and plasma membrane disruption. Ferroptosis is a form of cell death
that is mechanistically and morphologically distinct from other forms of cell death, such as necroptosis, apoptosis,
and…
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