grant
Noninvasive optical assessment of neuroprotection in deep hypothermic circulatory arrest procedures
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 6 May 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025Acquired brain injuryAffectAgreementAnesthesiaAnesthesia proceduresAnimalsAortic AneurysmApoplexyAreaAssayBilateralBioassayBiochemicalBiological AssayBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood TestsBlood VesselsBlood flowBody TissuesBrainBrain InjuriesBrain IschemiaBrain Nervous SystemBrain Vascular AccidentBrain hemodynamicsCardiac SurgeryCardiac Surgery proceduresCardiopulmonary BypassCell Communication and SignalingCell SignalingCerebral IschemiaCerebral StrokeCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular StrokeCerebrumCharacteristicsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalComplexConsensusDataDeliriumDevelopmentDiagnosisDiffuseDissectionDisturbance in cognitionDoppler Transcranial SonographyEffectivenessEmbolismEmbolusEncephalonEvaluationFrequenciesGeneral HospitalsGenerationsGoalsHealth Care CostsHealth CostsHeart Surgical ProceduresHeart-Lung BypassHematologic TestsHematological TestsHematology TestingHypothermiaHypoxiaHypoxicIQ DeficitImpaired cognitionImpairmentIncidenceInjuryIntermediary MetabolismInterventionIntervention TrialInterventional trialIntracellular Communication and SignalingIschemiaIschemic EncephalopathyLesionLightMR ImagingMR TomographyMRIMRI ScansMRIsMT-bound tauMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMeasurementMeasuresMedical ImagingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolic ProcessesMetabolismMonitorMorbidityMorbidity - disease rateNIR SpectroscopyNMR ImagingNMR TomographyNear-Infrared SpectrometryNear-Infrared SpectroscopyNervous System InjuriesNervous System TraumaNervous System damageNeurocognitive DeficitNeurologicNeurologic DysfunctionsNeurologic outcomeNeurologicalNeurological DamageNeurological InjuryNeurological outcomeNeurological traumaNuclear Magnetic Resonance ImagingO elementO2 elementObservation researchObservation studyObservational StudyObservational researchOperative ProceduresOperative Surgical ProceduresOpticsOxygenOxygen DeficiencyPatient RecruitmentsPatientsPerfusionPhotoradiationPlasmaPlasma SerumPostoperativePostoperative PeriodPrecision careProceduresQOLQuality of lifeRecordsReportingResearchReticuloendothelial System, Serum, PlasmaRiskRoleSignal TransductionSignal Transduction SystemsSignalingSpectroscopySpectrum AnalysesSpectrum AnalysisStrokeSurgicalSurgical InterventionsSurgical ProcedureTechniquesTechnologyTimeTissuesTranscranial Doppler UltrasonographyWorkZeugmatographyaortic archbio-markersbiologic markerbiological signal transductionbiomarkerbiomarker validationblood damageblood flow in brainbrain MR imagingbrain MRIbrain attackbrain blood circulationbrain blood dynamicsbrain blood flowbrain damagebrain healthbrain magnetic resonance imagingbrain metabolismbrain tissuebrain-injuredcerebralcerebral MR imagingcerebral MRIcerebral blood flowcerebral circulationcerebral hemodynamicscerebral magnetic resonance imagingcerebral vascular accidentcerebrocirculationcerebrovascular accidentcerebrovascular blood flowcognitive assessmentcognitive defectscognitive dysfunctioncognitive losscognitive testingcontinuous monitoringdeliriousdevelopmentalelderly patientencephalographyheart bypassheart surgeryhemodynamicsimprovedindividualized careindividualized patient careinjuriesinjury to the myocardiuminstrumentationintelligence quotient deficitintervention designmarker validationmetabolic ratemicrotubule bound taumicrotubule-bound taumortalitymyocardial injurynatural hypothermianeurocognitive declineneurocognitive impairmentneurofilamentneurological dysfunctionneuroprotectionneuroprotectiveneurotoxicneurotraumanovelolder patientopticalp-taup-τparticipant recruitmentpersonalized carepersonalized patient carephospho-tauphospho-τphosphorylated taupost-operative deliriumpost-translational modification of taupostoperative deliriumposttranslational modification of tausocial rolestrokedstrokessurgerytautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1therapy designtooltranscranial doppler ultrasoundtreatment designvascularτ Proteinsτ phosphorylation
Description preview
PROJECT SUMMARY
Neurologic dysfunction is a major concern for patients and clinicians as it significantly contributes to high
morbidity and mortality, negatively affect patients’ quality of life and increase healthcare cost. Despite substantial
technological advancements in surgery, cardiopulmonary bypass (CPB) and anesthesia, cardiac surgery…
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